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Literature summary for 3.3.2.9 extracted from
- Mammalian epoxide hydrolases in xenobiotic metabolism and signalling (2009), Arch. Toxicol., 83, 297-318.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| N-acetylaminofluorene | - |
Mus musculus |  |
| N-acetylaminofluorene | - |
Homo sapiens | |
| Phenobarbitone | - |
Mus musculus | |
| Phenobarbitone | - |
Homo sapiens | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Mus musculus |
| expressed in Escherichia coli | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| elaidamide | - |
Homo sapiens | |
| elaidamide | - |
Mus musculus | |
| trichloropropene oxide | - |
Homo sapiens | |
| trichloropropene oxide | - |
Mus musculus | |
| valpromide | - |
Homo sapiens | |
| valpromide | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | mEH is capable of inactivating a large number of structurally different, highly reactive epoxides and hence is an important part of the enzymatic defence of our organism against adverse effects of foreign compounds | ? | - |
? | |
| additional information | Homo sapiens | mEH is capable of inactivating a large number of structurally different, highly reactive epoxides and hence is an important part of the enzymatic defence of our organism against adverse effects of foreign compounds | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | high expression level of mEH in the liver | Mus musculus | - |
| liver | high expression level of mEH in the liver | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O | i.e. 11,12-EET | Mus musculus | (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid | i.e. 11,12-DHET | ? | |
| (5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O | i.e. 11,12-EET | Homo sapiens | (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid | i.e. 11,12-DHET | ? | |
| aflatoxin-B1-8,9-exo-epoxide + H2O | - |
Mus musculus | ? | - |
? | |
| aflatoxin-B1-8,9-exo-epoxide + H2O | - |
Homo sapiens | ? | - |
? | |
| benzo[a]pyrene-7,8-epoxide + H2O | - |
Mus musculus | benzo[a]pyrene-7,8-dihydrodiol | - |
? | |
| benzo[a]pyrene-7,8-epoxide + H2O | - |
Homo sapiens | benzo[a]pyrene-7,8-dihydrodiol | - |
? | |
| carbamazepine-10,11-epoxide + H2O | - |
Mus musculus | ? | - |
? | |
| carbamazepine-10,11-epoxide + H2O | - |
Homo sapiens | ? | - |
? | |
| cis-stilbene oxide + H2O | - |
Mus musculus | (1R,2R)-1,2-diphenylethane-1,2-diol | - |
? | |
| cis-stilbene oxide + H2O | - |
Homo sapiens | (1R,2R)-1,2-diphenylethane-1,2-diol | - |
? | |
| ethylene oxide + H2O | - |
Mus musculus | ethane-1,2-diol | - |
? | |
| ethylene oxide + H2O | - |
Homo sapiens | ethane-1,2-diol | - |
? | |
| additional information | mEH is capable of inactivating a large number of structurally different, highly reactive epoxides and hence is an important part of the enzymatic defence of our organism against adverse effects of foreign compounds | Mus musculus | ? | - |
? | |
| additional information | mEH is capable of inactivating a large number of structurally different, highly reactive epoxides and hence is an important part of the enzymatic defence of our organism against adverse effects of foreign compounds | Homo sapiens | ? | - |
? | |
| styrene oxide + H2O | - |
Mus musculus | 1-phenylethane-1,2-diol | - |
? | |
| styrene oxide + H2O | - |
Homo sapiens | 1-phenylethane-1,2-diol | - |
? | |
| styrene-7,8-oxide + H2O | - |
Mus musculus | 1-phenylethane-1,2-diol | - |
? | |
| styrene-7,8-oxide + H2O | - |
Homo sapiens | 1-phenylethane-1,2-diol | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Mus musculus |
| dimer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EPHX1 | - |
Mus musculus |
| EPHX1 | - |
Homo sapiens |
| mEH | - |
Mus musculus |
| mEH | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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