Literature summary for 3.3.2.9 extracted from

Robien, K.; Curtin, K.; Ulrich, C.M.; Bigler, J.; Samowitz, W.; Caan, B.; Potter, J.D.; Slattery, M.L.
Microsomal epoxide hydrolase polymorphisms are not associated with colon cancer risk (2005), Cancer Epidemiol. Biomarkers Prev., 14, 1350-1352.

Search for more literature for 3.3.2.9

Cloned(Commentary)

Cloned (Comment)	Organism
genotyping of 3553 humans	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
H139R	natural genotype, frequency of the polymorphism, the mutant enzyme shows 25% increased activity compared to the wild-type enzyme	Homo sapiens
additional information	genotyping of 3553 humans, enzyme polymorphisms are not associated with colon cancer	Homo sapiens
Y113H	natural genotype, frequency of the polymorphism, the mutant enzyme shows 40% reduced activity compared to the wild-type enzyme	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	the enzyme is a phase II biotransformation enzyme which detoxifies epoxides, including carcinogens such as polycyclic aromatic hydrocarbons found in cigarette smoke and cooked meats, enzyme polymorphisms are not associated with colon cancer risk	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is a phase II biotransformation enzyme which detoxifies epoxides, including carcinogens such as polycyclic aromatic hydrocarbons found in cigarette smoke and cooked meats, enzyme polymorphisms are not associated with colon cancer risk	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
mEH	-	Homo sapiens

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Release 2023.1 (January 2023)