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Literature summary for 3.3.2.9 extracted from

  • Dietze, E.C.; Kuwano, E.; Casa, J.; Hammock, B.D.
    Inhibition of cytosolic epoxide hydrolase by trans-3-phenylglycidols (1991), Biochem. Pharmacol., 42, 1163-1175.
    View publication on PubMed
Search for more literature for 3.3.2.9

Activating Compound

Activating Compound Comment Organism Structure
additional information clofibrate induces the enzyme Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
(1R,2R)-1,2-epoxy-1-phenyl-1-propane 88% inhibition at 0.8 mM Mus musculus
(1S,2S)-1,2-epoxy-1-phenyl-1-propane 89% inhibition at 0.8 mM Mus musculus
(2R,3R)-1-benzyloxy-2,3-epoxy-3-(4-nitrophenyl)propane 9.0% inhibition at 0.1 mM Mus musculus
(2R,3R)-3-(4-nitrophenyl)glycidol 8.2% inhibition at 0.2 mM Mus musculus
(2S,3S)-1-benzyloxy-2,3-epoxy-3-(4-nitrophenyl)propane 11% inhibition at 0.1 mM Mus musculus
(2S,3S)-3-(4-nitrophenyl)glycidol 17% inhibition at 0.2 mM Mus musculus
7-oxabicyclo[4.1.0]heptane IC50 is 0.0022 mM Mus musculus
additional information no inhibition by 3-phenylglycidol enantiomers, inhibitor synthesis, overview, inhibition mechanisms, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 Swiss Webster mice
-

Purification (Commentary)

Purification (Comment) Organism
from liver microsomes Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
mEH
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
 assay at Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0022
-
 IC50 is 0.0022 mM Mus musculus 7-oxabicyclo[4.1.0]heptane