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Literature summary for 3.3.2.9 extracted from
- Distinct rat hepatic microsomal epoxide hydrolases catalyze the hydration of cholesterol 5,6alpha-oxide and certain xenobiotic alkene and arene oxides (1983), Arch. Biochem. Biophys., 220, 485-494.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no effect by cholestyramine and clofibrate, phenobarbital and isosafrole induce the enzyme expression, it is also induced by trans-stilbene oxide, gamma-chlordane, Aroclor 1254, and 2-acetylamineo-fluorene in liver microsomes | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | 5,6alpha-epoxy-5alpha-cholestan-3beta-ol causes down-regulation of the enzyme, no effect by cholestyramine and clofibrate | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | the enzyme metabolizes xenobiotic epoxides | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Long Evans rats | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| to homogeneity from liver of phenobarbital- and isosafrole-treated rats, separation from the cholesterol 5,6-oxide hydrolase, EC 3.3.2.11, by immunoprecipitation | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benz[a]anthracene 5,6-oxide + H2O | - |
Rattus norvegicus | 5,6-dihydro-chrysene-5,6-diol | - |
? | |
| additional information | the enzyme metabolizes xenobiotic epoxides | Rattus norvegicus | ? | - |
? | |
| additional information | the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.11, which specifically utilizes 5,6alpha-epoxy-5alpha-cholestan-3beta-ol, that is no substrate for EC 3.3.2.9 | Rattus norvegicus | ? | - |
? | |
| octene 1,2-oxide + H2O | - |
Rattus norvegicus | octan-1,2-diol | - |
? | |
| styrene 7,8-oxide + H2O | - |
Rattus norvegicus | 1-phenyl-ethane-1,2-diol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| microsomal xenobiotic epoxide hydrolase | - |
Rattus norvegicus |
| xenobiotic epoxide hydrolase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
- |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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