Any feedback?
Literature summary for 3.3.2.9 extracted from
- Epoxide hydratase (1977), Mises Point Biochim. Pharmacol., 1, 127-148.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3,3,3-trichloropropene oxide | - |
Cavia porcellus |  |
| 3,3,3-trichloropropene oxide | - |
Homo sapiens | |
| 3,3,3-trichloropropene oxide | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.67 | - |
styrene oxide | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Cavia porcellus | - |
- |
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Oryctolagus cuniculus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 49000 | - |
x * 49000, SDS-PAGE | Homo sapiens |
| 49000 | - |
x * 49000, SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Cavia porcellus | - |
? | - |
? | |
| additional information | Mus musculus | - |
? | - |
? | |
| additional information | Rattus norvegicus | - |
? | - |
? | |
| additional information | Homo sapiens | the enzyme is expected to play a purely protective role with respect to epoxides metabolically produced from pharmaceutical drugs | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Macaca mulatta | - |
- |
- |
| Mus musculus | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | - |
enzyme activity is about 2.5 to 3 times higher in male than in female | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Cavia porcellus | - |
| adrenal gland | - |
Homo sapiens | - |
| adrenal gland | - |
Rattus norvegicus | - |
| bladder | - |
Rattus norvegicus | - |
| brain | - |
Cavia porcellus | - |
| brain | - |
Rattus norvegicus | - |
| cecum | - |
Rattus norvegicus | - |
| colon | - |
Rattus norvegicus | - |
| dermis | - |
Rattus norvegicus | - |
| epidermis | - |
Rattus norvegicus | - |
| esophagus | - |
Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| kidney | - |
Mus musculus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| kidney | - |
Oryctolagus cuniculus | - |
| kidney | - |
Macaca mulatta | - |
| liver | - |
Cavia porcellus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Oryctolagus cuniculus | - |
| liver | - |
Macaca mulatta | - |
| lung | - |
Rattus norvegicus | - |
| lung | - |
Oryctolagus cuniculus | - |
| muscle | triceps | Rattus norvegicus | - |
| ovary | - |
Rattus norvegicus | - |
| prostate gland | - |
Rattus norvegicus | - |
| small intestine | - |
Cavia porcellus | - |
| small intestine | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
| stomach | membranous and glandular | Rattus norvegicus | - |
| subcutis | - |
Rattus norvegicus | - |
| submandibular gland | - |
Rattus norvegicus | - |
| testis | - |
Mus musculus | - |
| testis | - |
Homo sapiens | - |
| testis | - |
Rattus norvegicus | - |
| testis | - |
Oryctolagus cuniculus | - |
| testis | - |
Macaca mulatta | - |
| thymus | - |
Rattus norvegicus | - |
| tongue | - |
Rattus norvegicus | - |
| trachea | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.516 | - |
- |
Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 0°C, 50 mM sodium phosphate buffer, pH 7.0, 2 months, stable | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | - |
Cavia porcellus | ? | - |
? | |
| additional information | - |
Mus musculus | ? | - |
? | |
| additional information | - |
Rattus norvegicus | ? | - |
? | |
| additional information | the enzyme is expected to play a purely protective role with respect to epoxides metabolically produced from pharmaceutical drugs | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | - |
Cavia porcellus |
| ? | - |
Mus musculus |
| ? | x * 49000, SDS-PAGE | Homo sapiens |
| ? | x * 49000, SDS-PAGE | Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
pH 7.0, 5 h, stable | Rattus norvegicus |
| 37 | - |
- |
Mus musculus |
| 37 | - |
- |
Homo sapiens |
| 37 | - |
pH 7.0, 24 h, less than 10% inactivation | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.9 | - |
hydration of styrene oxide, Tris buffer | Rattus norvegicus |
| 9 | - |
- |
Mus musculus |
| 9 | - |
hydration of styrene oxide in sodium phosphate buffer | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
