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Literature summary for 3.3.2.10 extracted from
- Epoxide hydrolases: their roles and interactions with lipid metabolism (2005), Prog. Lipid Res., 44, 1-51.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth | Vicia sativa | |
| additional information | inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth | Triticum aestivum | |
| additional information | inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth | Spinacia oleracea | |
| additional information | inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth | Brassica napus | |
| additional information | inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth | Ricinus communis | |
| additional information | inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth | Apium graveolens | |
| additional information | inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth | Oryza sativa | |
| additional information | inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth | Ananas comosus | |
| additional information | inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth | Euphorbia lagascae | |
| additional information | inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth | Malus pumila | |
| additional information | inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth, ethylene induces the enzyme in germinating seeds | Glycine max | |
| additional information | inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth, pathogenic fungus infection induces the enzyme in leaves | Citrus jambhiri | |
| additional information | inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth, viral infection of the aerial body and the plant induces the enzyme | Nicotiana tabacum | |
| additional information | inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, growth, the enzyme is not affected by cytokinin, abscisic acid, 6-benzylaminopurine, or gibberellin, but highly by methyl jasmonate, auxin, and ethylene, wounding induces the enzyme in leaves | Solanum tuberosum | |
| additional information | inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, growth, the enzyme is not affected by cytokinin, abscisic acid, 6-benzylaminopurine, or gibberellin, while auxin, 2,4-dichlorophenoxy acetic acid, and naphthalene acetic acid induce the enzyme in stem and leaves, drought stress slightly induces the enzmye in stem and leaves | Arabidopsis thaliana | |
| additional information | the enzyme is induced by clofibrate | Cavia porcellus | |
| additional information | the enzyme is induced by clofibrate | Homo sapiens | |
| additional information | the enzyme is induced by clofibrate | Rattus norvegicus | |
| additional information | the enzyme is induced by clofibrate | Sus scrofa | |
| additional information | the enzyme is induced by clofibrate | Oryctolagus cuniculus | |
| additional information | the enzyme is induced by clofibrate | Mesocricetus auratus | |
| additional information | the enzyme is induced by clofibrate | Equus caballus | |
| additional information | the enzyme is induced by clofibrate | Macaca mulatta | |
| additional information | the enzyme is induced by clofibrate | Papio sp. | |
| additional information | the enzyme is induced by clofibrate | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | enzyme polymorphisms, overview | Homo sapiens |
| R287E | naturally occuring mutation of gene EPXH2 leads to elevated plasma cholesterol and triglycerides | Homo sapiens |
| R287Q | naturally occuring mutation of gene EPXH2 leads to elevated risk of coronary artery calcification found in African Americans | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Vicia sativa | 5829 | - |
| cytosol | - |
Cavia porcellus | 5829 | - |
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | - |
Sus scrofa | 5829 | - |
| cytosol | - |
Triticum aestivum | 5829 | - |
| cytosol | - |
Oryctolagus cuniculus | 5829 | - |
| cytosol | - |
Spinacia oleracea | 5829 | - |
| cytosol | - |
Zea mays | 5829 | - |
| cytosol | - |
Solanum tuberosum | 5829 | - |
| cytosol | - |
Nicotiana tabacum | 5829 | - |
| cytosol | - |
Glycine max | 5829 | - |
| cytosol | - |
Arabidopsis thaliana | 5829 | - |
| cytosol | - |
Brassica napus | 5829 | - |
| cytosol | - |
Ricinus communis | 5829 | - |
| cytosol | - |
Mesocricetus auratus | 5829 | - |
| cytosol | - |
Equus caballus | 5829 | - |
| cytosol | - |
Apium graveolens | 5829 | - |
| cytosol | - |
Macaca mulatta | 5829 | - |
| cytosol | - |
Oryza sativa | 5829 | - |
| cytosol | - |
Oncorhynchus mykiss | 5829 | - |
| cytosol | - |
Ananas comosus | 5829 | - |
| cytosol | - |
Oryzias latipes | 5829 | - |
| cytosol | - |
Papio sp. | 5829 | - |
| cytosol | - |
Euphorbia lagascae | 5829 | - |
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Citrus jambhiri | 5829 | - |
| cytosol | - |
Malus pumila | 5829 | - |
| cytosol | - |
Pimephales promelas | 5829 | - |
| cytosol | - |
Stenotomus chrysops | 5829 | - |
| glyoxysome | - |
Ricinus communis | 9514 | - |
| peroxisome | in the light mitochondrial fraction | Mus musculus | 5777 | - |
| peroxisome | the enzyme contains an impaired peroxisomal targeting sequence leading to dual localization | Rattus norvegicus | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 35000 | - |
n * 35000, about | Solanum tuberosum |
| 35000 | - |
n * 35000, about | Glycine max |
| 35000 | - |
n * 35000, about | Arabidopsis thaliana |
| 35000 | - |
n * 35000, about | Ricinus communis |
| 35000 | - |
x * 35000, about | Vicia sativa |
| 35000 | - |
x * 35000, about | Triticum aestivum |
| 35000 | - |
x * 35000, about | Spinacia oleracea |
| 35000 | - |
x * 35000, about | Nicotiana tabacum |
| 35000 | - |
x * 35000, about | Brassica napus |
| 35000 | - |
x * 35000, about | Apium graveolens |
| 35000 | - |
x * 35000, about | Oryza sativa |
| 35000 | - |
x * 35000, about | Ananas comosus |
| 35000 | - |
x * 35000, about | Euphorbia lagascae |
| 35000 | - |
x * 35000, about | Citrus jambhiri |
| 35000 | - |
x * 35000, about | Malus pumila |
| 62000 | - |
2 * 62000, about | Cavia porcellus |
| 62000 | - |
2 * 62000, about | Homo sapiens |
| 62000 | - |
2 * 62000, about | Rattus norvegicus |
| 62000 | - |
2 * 62000, about | Sus scrofa |
| 62000 | - |
2 * 62000, about | Oryctolagus cuniculus |
| 62000 | - |
2 * 62000, about | Mesocricetus auratus |
| 62000 | - |
2 * 62000, about | Equus caballus |
| 62000 | - |
2 * 62000, about | Macaca mulatta |
| 62000 | - |
2 * 62000, about | Papio sp. |
| 62000 | - |
2 * 62000, about | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | Solanum tuberosum | - |
? | - |
? |  |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | Citrus jambhiri | - |
? | - |
? | |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | Malus pumila | step in cutin biosynthesis | ? | - |
? | |
| additional information | Homo sapiens | enzyme regulation, overview | ? | - |
? | |
| additional information | Oncorhynchus mykiss | enzyme regulation, overview | ? | - |
? | |
| additional information | Oryzias latipes | enzyme regulation, overview | ? | - |
? | |
| additional information | Pimephales promelas | enzyme regulation, overview | ? | - |
? | |
| additional information | Stenotomus chrysops | enzyme regulation, overview | ? | - |
? | |
| additional information | Vicia sativa | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | ? | - |
? | |
| additional information | Triticum aestivum | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | ? | - |
? | |
| additional information | Spinacia oleracea | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | ? | - |
? | |
| additional information | Zea mays | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | ? | - |
? | |
| additional information | Nicotiana tabacum | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | ? | - |
? | |
| additional information | Glycine max | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | ? | - |
? | |
| additional information | Arabidopsis thaliana | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | ? | - |
? | |
| additional information | Brassica napus | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | ? | - |
? | |
| additional information | Ricinus communis | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | ? | - |
? | |
| additional information | Apium graveolens | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | ? | - |
? | |
| additional information | Oryza sativa | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | ? | - |
? | |
| additional information | Ananas comosus | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | ? | - |
? | |
| additional information | Euphorbia lagascae | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | ? | - |
? | |
| additional information | Malus pumila | synthesis of anti-fungal substances in fruits, the enzyme is involved in host-defense and cutin biosynthesis, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | ? | - |
? | |
| additional information | Citrus jambhiri | the enzyme is involved in host-defense and cutin biosynthesis, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | ? | - |
? | |
| additional information | Solanum tuberosum | the enzyme is involved in host-defense and cutin biosynthesis, synthesis of (9S,10S,11R)-trihydroxy-12(Z)-octadecenoic and (9S,12S,13S)-trihydroxy-10(E)-octadecenoic acids with potent anti-fungal properties, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | ? | - |
? | |
| additional information | Cavia porcellus | the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview | ? | - |
? | |
| additional information | Rattus norvegicus | the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview | ? | - |
? | |
| additional information | Sus scrofa | the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview | ? | - |
? | |
| additional information | Oryctolagus cuniculus | the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview | ? | - |
? | |
| additional information | Mesocricetus auratus | the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview | ? | - |
? | |
| additional information | Equus caballus | the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview | ? | - |
? | |
| additional information | Macaca mulatta | the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview | ? | - |
? | |
| additional information | Papio sp. | the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lipid/carbohydrate metabolism, enzyme regulation, overview | ? | - |
? | |
| additional information | Mus musculus | the enzyme is involved in synthesis of tetrahydrofuran diol and trihydroxy furanyl lipids, enzyme regulation, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ananas comosus | - |
multiple isozymes, constitutive and inducible | - |
| Apium graveolens | - |
multiple isozymes, constitutive and inducible | - |
| Arabidopsis thaliana | - |
multiple isozymes, constitutive and inducible | - |
| Brassica napus | - |
multiple isozymes, constitutive and inducible | - |
| Cavia porcellus | - |
- |
- |
| Citrus jambhiri | - |
multiple isozymes, constitutive and inducible | - |
| Equus caballus | - |
- |
- |
| Euphorbia lagascae | - |
multiple isozymes, constitutive and inducible | - |
| Glycine max | - |
multiple isozymes, constitutive and inducible | - |
| Homo sapiens | - |
- |
- |
| Macaca mulatta | - |
- |
- |
| Malus pumila | - |
multiple isozymes, constitutive and inducible | - |
| Mesocricetus auratus | - |
- |
- |
| Mus musculus | P34914 | isozyme EPXH2B | - |
| Nicotiana tabacum | - |
multiple isozymes, constitutive and infection-induced | - |
| Oncorhynchus mykiss | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Oryza sativa | - |
multiple isozymes, constitutive and inducible | - |
| Oryzias latipes | - |
- |
- |
| Papio sp. | - |
baboon | - |
| Pimephales promelas | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Ricinus communis | - |
multiple isozymes, constitutive and inducible | - |
| Solanum tuberosum | - |
multiple isozymes, constitutive and inducible | - |
| Spinacia oleracea | - |
multiple isozymes, constitutive and inducible | - |
| Stenotomus chrysops | - |
- |
- |
| Sus scrofa | - |
- |
- |
| Triticum aestivum | - |
multiple isozymes, constitutive and inducible | - |
| Vicia sativa | - |
multiple isozymes, constitutive and inducible | - |
| Zea mays | - |
multiple isozymes | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| from liver | Cavia porcellus |
| from liver | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Homo sapiens | - |
| aerial part | - |
Nicotiana tabacum | - |
| brain | - |
Rattus norvegicus | - |
| endosperm | - |
Ricinus communis | - |
| endothelium | vascular | Homo sapiens | - |
| epididymis | - |
Homo sapiens | - |
| fruit | - |
Malus pumila | - |
| gonad | - |
Homo sapiens | - |
| heart | - |
Rattus norvegicus | - |
| intestine | - |
Homo sapiens | - |
| kidney | cortex | Homo sapiens | - |
| kidney | cortex | Rattus norvegicus | - |
| kidney | cortex | Mus musculus | - |
| leaf | - |
Nicotiana tabacum | - |
| leaf | - |
Arabidopsis thaliana | - |
| leaf | - |
Citrus jambhiri | - |
| leaf | meristem shows increased enzyme level compared to expanding and mature leaves | Solanum tuberosum | - |
| leukocyte | - |
Rattus norvegicus | - |
| liver | - |
Cavia porcellus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Mus musculus | - |
| lung | - |
Rattus norvegicus | - |
| lymph node | - |
Homo sapiens | - |
| mammary gland | - |
Mus musculus | - |
| additional information | tissue distribution | Vicia sativa | - |
| additional information | tissue distribution | Cavia porcellus | - |
| additional information | tissue distribution | Homo sapiens | - |
| additional information | tissue distribution | Rattus norvegicus | - |
| additional information | tissue distribution | Sus scrofa | - |
| additional information | tissue distribution | Triticum aestivum | - |
| additional information | tissue distribution | Oryctolagus cuniculus | - |
| additional information | tissue distribution | Spinacia oleracea | - |
| additional information | tissue distribution | Zea mays | - |
| additional information | tissue distribution | Solanum tuberosum | - |
| additional information | tissue distribution | Nicotiana tabacum | - |
| additional information | tissue distribution | Glycine max | - |
| additional information | tissue distribution | Arabidopsis thaliana | - |
| additional information | tissue distribution | Brassica napus | - |
| additional information | tissue distribution | Ricinus communis | - |
| additional information | tissue distribution | Mesocricetus auratus | - |
| additional information | tissue distribution | Equus caballus | - |
| additional information | tissue distribution | Apium graveolens | - |
| additional information | tissue distribution | Macaca mulatta | - |
| additional information | tissue distribution | Oryza sativa | - |
| additional information | tissue distribution | Oncorhynchus mykiss | - |
| additional information | tissue distribution | Ananas comosus | - |
| additional information | tissue distribution | Oryzias latipes | - |
| additional information | tissue distribution | Papio sp. | - |
| additional information | tissue distribution | Euphorbia lagascae | - |
| additional information | tissue distribution | Mus musculus | - |
| additional information | tissue distribution | Citrus jambhiri | - |
| additional information | tissue distribution | Malus pumila | - |
| additional information | tissue distribution | Pimephales promelas | - |
| additional information | tissue distribution | Stenotomus chrysops | - |
| muscle | striated | Mus musculus | - |
| ovary | - |
Homo sapiens | - |
| ovary | - |
Mus musculus | - |
| pancreas | - |
Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
| prostate | - |
Homo sapiens | - |
| seed | germinating | Glycine max | - |
| seed | germination-specific isozyme | Euphorbia lagascae | - |
| skin | - |
Rattus norvegicus | - |
| smooth muscle | - |
Homo sapiens | - |
| spleen | - |
Rattus norvegicus | - |
| stem | - |
Arabidopsis thaliana | - |
| stomach | - |
Homo sapiens | - |
| testis | - |
Rattus norvegicus | - |
| tonsil | - |
Homo sapiens | - |
| urinary bladder | - |
Homo sapiens | - |
| uterus | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 11,12-leukotriene A4 + H2O | - |
Cavia porcellus | ? | - |
? | |
| 11R,12S-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | 11R,12S-dihydroxyeicosatrienoic acid | - |
? | |
| 11S,12R-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | 11S,12R-hydroxyeicosatrienoic acid | - |
? | |
| 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O | - |
Vicia sativa | ? | - |
? | |
| 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O | - |
Triticum aestivum | ? | - |
? | |
| 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O | - |
Spinacia oleracea | ? | - |
? | |
| 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O | - |
Zea mays | ? | - |
? | |
| 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O | - |
Solanum tuberosum | ? | - |
? | |
| 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O | - |
Nicotiana tabacum | ? | - |
? | |
| 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O | - |
Glycine max | ? | - |
? | |
| 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O | - |
Arabidopsis thaliana | ? | - |
? | |
| 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O | - |
Brassica napus | ? | - |
? | |
| 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O | - |
Ricinus communis | ? | - |
? | |
| 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O | - |
Apium graveolens | ? | - |
? | |
| 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O | - |
Oryza sativa | ? | - |
? | |
| 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O | - |
Ananas comosus | ? | - |
? | |
| 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O | - |
Euphorbia lagascae | ? | - |
? | |
| 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O | - |
Citrus jambhiri | ? | - |
? | |
| 12,13-epoxy octadeca-(9Z)-eneoic acid + H2O | - |
Malus pumila | ? | - |
? | |
| 14,15-leukotriene A4 + H2O | - |
Cavia porcellus | ? | - |
? | |
| 14R,15S-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | 14R,15S-dihydroxyeicosatrienoic acid | - |
? | |
| 14S,15R-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | 14S,15R-dihydroxyeicosatrienoic acid | - |
? | |
| 14S,15S-trans-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoic acid + H2O | - |
Mus musculus | 14S,15R-dihydroxy-(5Z,8Z,10E,12E)-eicosatetraenoic acid | - |
? | |
| 5,6-leukotriene A4 + H2O | - |
Cavia porcellus | ? | - |
? | |
| 8R,9S-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | 8R,9S-dihydroxyeicosatrienoic acid | - |
? | |
| 8S,9R-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | 8S,9R-dihydroxyeicosatrienoic acid | - |
? | |
| 9(10),12(13)-diepoxyoctadecanoic acid + H2O | - |
Mus musculus | 9,10,12,13-tetrahydroxyoctadecanoic acid | - |
? | |
| 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Vicia sativa | ? | - |
? | |
| 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Spinacia oleracea | ? | - |
? | |
| 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Arabidopsis thaliana | ? | - |
? | |
| 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Brassica napus | ? | - |
? | |
| 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Ricinus communis | ? | - |
? | |
| 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Ananas comosus | ? | - |
? | |
| 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Euphorbia lagascae | ? | - |
? | |
| 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Citrus jambhiri | ? | - |
? | |
| 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Malus pumila | ? | - |
? | |
| 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O | no enantioselectivity | Triticum aestivum | ? | - |
? | |
| 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O | no enantioselectivity | Zea mays | ? | - |
? | |
| 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O | no enantioselectivity | Oryza sativa | ? | - |
? | |
| 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O | no enantioselectivity of infection-induced isozymes, conversion of the (S)-carbon to the corresponding threo-(R,R)-diol in over 85% | Nicotiana tabacum | ? | - |
? | |
| 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O | the enzyme prefers the (9R,10S)-enantiomer | Apium graveolens | ? | - |
? | |
| 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O | the enzyme prefers the (9R,10S)-enantiomer, conversion of the (S)-carbon to the corresponding threo-(R,R)-diol in over 85% | Solanum tuberosum | ? | - |
? | |
| 9,10-epoxy octadeca-(12Z)-eneoic acid + H2O | the enzyme strongly prefers the (9R,10S)-enantiomer, conversion of the (S)-carbon to the corresponding threo-(R,R)-diol in over 85% | Glycine max | ? | - |
? | |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | - |
Vicia sativa | ? | - |
? | |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | - |
Triticum aestivum | ? | - |
? | |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | - |
Spinacia oleracea | ? | - |
? | |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | - |
Zea mays | ? | - |
? | |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | - |
Solanum tuberosum | ? | - |
? | |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | - |
Nicotiana tabacum | ? | - |
? | |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | - |
Glycine max | ? | - |
? | |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | - |
Arabidopsis thaliana | ? | - |
? | |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | - |
Brassica napus | ? | - |
? | |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | - |
Ricinus communis | ? | - |
? | |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | - |
Apium graveolens | ? | - |
? | |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | - |
Oryza sativa | ? | - |
? | |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | - |
Ananas comosus | ? | - |
? | |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | - |
Euphorbia lagascae | ? | - |
? | |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | - |
Citrus jambhiri | ? | - |
? | |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | - |
Malus pumila | ? | - |
? | |
| 9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O | step in cutin biosynthesis | Malus pumila | ? | - |
? | |
| 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Vicia sativa | ? | - |
? | |
| 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Triticum aestivum | ? | - |
? | |
| 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Spinacia oleracea | ? | - |
? | |
| 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Zea mays | ? | - |
? | |
| 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Solanum tuberosum | ? | - |
? | |
| 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Nicotiana tabacum | ? | - |
? | |
| 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Glycine max | ? | - |
? | |
| 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Arabidopsis thaliana | ? | - |
? | |
| 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Brassica napus | ? | - |
? | |
| 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Ricinus communis | ? | - |
? | |
| 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Apium graveolens | ? | - |
? | |
| 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Oryza sativa | ? | - |
? | |
| 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Ananas comosus | ? | - |
? | |
| 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Euphorbia lagascae | ? | - |
? | |
| 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Citrus jambhiri | ? | - |
? | |
| 9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O | - |
Malus pumila | ? | - |
? | |
| additional information | enzyme regulation, overview | Homo sapiens | ? | - |
? | |
| additional information | enzyme regulation, overview | Oncorhynchus mykiss | ? | - |
? | |
| additional information | enzyme regulation, overview | Oryzias latipes | ? | - |
? | |
| additional information | enzyme regulation, overview | Pimephales promelas | ? | - |
? | |
| additional information | enzyme regulation, overview | Stenotomus chrysops | ? | - |
? | |
| additional information | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | Vicia sativa | ? | - |
? | |
| additional information | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | Triticum aestivum | ? | - |
? | |
| additional information | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | Spinacia oleracea | ? | - |
? | |
| additional information | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | Zea mays | ? | - |
? | |
| additional information | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | Nicotiana tabacum | ? | - |
? | |
| additional information | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | Glycine max | ? | - |
? | |
| additional information | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | Arabidopsis thaliana | ? | - |
? | |
| additional information | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | Brassica napus | ? | - |
? | |
| additional information | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | Ricinus communis | ? | - |
? | |
| additional information | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | Apium graveolens | ? | - |
? | |
| additional information | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | Oryza sativa | ? | - |
? | |
| additional information | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | Ananas comosus | ? | - |
? | |
| additional information | preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | Euphorbia lagascae | ? | - |
? | |
| additional information | synthesis of anti-fungal substances in fruits, the enzyme is involved in host-defense and cutin biosynthesis, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | Malus pumila | ? | - |
? | |
| additional information | the enzyme is involved in host-defense and cutin biosynthesis, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | Citrus jambhiri | ? | - |
? | |
| additional information | the enzyme is involved in host-defense and cutin biosynthesis, synthesis of (9S,10S,11R)-trihydroxy-12(Z)-octadecenoic and (9S,12S,13S)-trihydroxy-10(E)-octadecenoic acids with potent anti-fungal properties, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins | Solanum tuberosum | ? | - |
? | |
| additional information | the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview | Cavia porcellus | ? | - |
? | |
| additional information | the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview | Rattus norvegicus | ? | - |
? | |
| additional information | the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview | Sus scrofa | ? | - |
? | |
| additional information | the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview | Oryctolagus cuniculus | ? | - |
? | |
| additional information | the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview | Mesocricetus auratus | ? | - |
? | |
| additional information | the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview | Equus caballus | ? | - |
? | |
| additional information | the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview | Macaca mulatta | ? | - |
? | |
| additional information | the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lipid/carbohydrate metabolism, enzyme regulation, overview | Papio sp. | ? | - |
? | |
| additional information | the enzyme is involved in synthesis of tetrahydrofuran diol and trihydroxy furanyl lipids, enzyme regulation, overview | Mus musculus | ? | - |
? | |
| additional information | plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides | Vicia sativa | ? | - |
? | |
| additional information | plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides | Triticum aestivum | ? | - |
? | |
| additional information | plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides | Spinacia oleracea | ? | - |
? | |
| additional information | plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides | Zea mays | ? | - |
? | |
| additional information | plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides | Solanum tuberosum | ? | - |
? | |
| additional information | plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides | Nicotiana tabacum | ? | - |
? | |
| additional information | plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides | Glycine max | ? | - |
? | |
| additional information | plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides | Arabidopsis thaliana | ? | - |
? | |
| additional information | plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides | Brassica napus | ? | - |
? | |
| additional information | plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides | Ricinus communis | ? | - |
? | |
| additional information | plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides | Apium graveolens | ? | - |
? | |
| additional information | plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides | Oryza sativa | ? | - |
? | |
| additional information | plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides | Ananas comosus | ? | - |
? | |
| additional information | plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides | Euphorbia lagascae | ? | - |
? | |
| additional information | plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides | Citrus jambhiri | ? | - |
? | |
| additional information | plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides | Malus pumila | ? | - |
? | |
| additional information | substrate specificity, the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates, except for the isozyme EPXH2B, overview | Mus musculus | ? | - |
? | |
| additional information | the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates | Cavia porcellus | ? | - |
? | |
| additional information | the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates | Sus scrofa | ? | - |
? | |
| additional information | the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates | Oryctolagus cuniculus | ? | - |
? | |
| additional information | the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates | Mesocricetus auratus | ? | - |
? | |
| additional information | the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates | Equus caballus | ? | - |
? | |
| additional information | the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates | Macaca mulatta | ? | - |
? | |
| additional information | the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates | Papio sp. | ? | - |
? | |
| additional information | the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates, overview | Homo sapiens | ? | - |
? | |
| additional information | the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates, overview | Rattus norvegicus | ? | - |
? | |
| squalene diepoxide + H2O | - |
Mus musculus | ? | - |
? | |
| squalene-2,3-epoxide + H2O | - |
Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 62000, about | Cavia porcellus |
| dimer | 2 * 62000, about | Homo sapiens |
| dimer | 2 * 62000, about | Rattus norvegicus |
| dimer | 2 * 62000, about | Sus scrofa |
| dimer | 2 * 62000, about | Oryctolagus cuniculus |
| dimer | 2 * 62000, about | Mesocricetus auratus |
| dimer | 2 * 62000, about | Equus caballus |
| dimer | 2 * 62000, about | Macaca mulatta |
| dimer | 2 * 62000, about | Papio sp. |
| dimer | 2 * 62000, about | Mus musculus |
| monomer or dimer | n * 35000, about | Solanum tuberosum |
| monomer or dimer | n * 35000, about | Glycine max |
| monomer or dimer | n * 35000, about | Arabidopsis thaliana |
| monomer or dimer | n * 35000, about | Ricinus communis |
| monomer or dimer | x * 35000, about | Vicia sativa |
| monomer or dimer | x * 35000, about | Triticum aestivum |
| monomer or dimer | x * 35000, about | Spinacia oleracea |
| monomer or dimer | x * 35000, about | Nicotiana tabacum |
| monomer or dimer | x * 35000, about | Brassica napus |
| monomer or dimer | x * 35000, about | Apium graveolens |
| monomer or dimer | x * 35000, about | Oryza sativa |
| monomer or dimer | x * 35000, about | Ananas comosus |
| monomer or dimer | x * 35000, about | Euphorbia lagascae |
| monomer or dimer | x * 35000, about | Citrus jambhiri |
| monomer or dimer | x * 35000, about | Malus pumila |
| More | the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates | Cavia porcellus |
| More | the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates | Homo sapiens |
| More | the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates | Rattus norvegicus |
| More | the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates | Sus scrofa |
| More | the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates | Oryctolagus cuniculus |
| More | the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates | Mesocricetus auratus |
| More | the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates | Equus caballus |
| More | the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates | Macaca mulatta |
| More | the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates | Papio sp. |
| More | the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EPXH2 | - |
Homo sapiens |
| EPXH2B | - |
Mus musculus |
| SEH | - |
Vicia sativa |
| SEH | - |
Rattus norvegicus |
| SEH | - |
Triticum aestivum |
| SEH | - |
Spinacia oleracea |
| SEH | - |
Zea mays |
| SEH | - |
Solanum tuberosum |
| SEH | - |
Nicotiana tabacum |
| SEH | - |
Glycine max |
| SEH | - |
Arabidopsis thaliana |
| SEH | - |
Brassica napus |
| SEH | - |
Ricinus communis |
| SEH | - |
Apium graveolens |
| SEH | - |
Oryza sativa |
| SEH | - |
Ananas comosus |
| SEH | - |
Papio sp. |
| SEH | - |
Euphorbia lagascae |
| SEH | - |
Citrus jambhiri |
| SEH | - |
Malus pumila |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Cavia porcellus | - |
6 | 5 |
| Rattus norvegicus | - |
6 | 5 |
| Sus scrofa | - |
6 | 5 |
| Oryctolagus cuniculus | - |
6 | 5 |
| Mesocricetus auratus | - |
6 | 5 |
| Equus caballus | - |
6 | 5 |
| Macaca mulatta | - |
6 | 5 |
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Release 2023.1 (January 2023)
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