Literature summary for 3.2.2.28 extracted from

Mokkapati, S.K.; Fernandez de Henestrosa, A.R.; Bhagwat, A.S.
Escherichia coli DNA glycosylase Mug: a growth-regulated enzyme required for mutation avoidance in stationary-phase cells (2001), Mol. Microbiol., 41, 1101-1111.

Search for more literature for 3.2.2.28

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Escherichia coli	Mug is expressed poorly in exponentially growing cells and has no apparent role in mutation avoidance in these cells. Mug is fairly abundant in stationary-phase cells and has an important anti-mutator role at this stage of cell growth	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0A9H1	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Escherichia coli

Source Tissue

Source Tissue	Comment	Organism	Textmining
cell culture	poorly expressed in exponentially growing cells. Mug is overexpressed as cells enter stationary phase, and it is maintained at a fairly high level in resting cells. This is true of cells grown in rich or minimal media, and the principal regulation of mug is at the level of mRNA. Although the expression of mug is strongly dependent on the stationary-phase sigma factor, when cells are grown in minimal media, it shows only a modest dependence on stationary-phase sigma factor when cells are grown in rich media	Escherichia coli	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3,N4-ethenocytosine-mismatched double-stranded DNA + H2O	-	Escherichia coli	3,N4-ethenocytosine + double-stranded DNA with abasic site	-	?
additional information	Mug is expressed poorly in exponentially growing cells and has no apparent role in mutation avoidance in these cells. Mug is fairly abundant in stationary-phase cells and has an important anti-mutator role at this stage of cell growth	Escherichia coli	?	-	?

Synonyms

Synonyms	Comment	Organism
MUG	-	Escherichia coli

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)