Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.2.27 extracted from

  • Weil, A.F.; Ghosh, D.; Zhou, Y.; Seiple, L.; McMahon, M.A.; Spivak, A.M.; Siliciano, R.F.; Stivers, J.T.
    Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration (2013), Proc. Natl. Acad. Sci. USA, 110, E448-E457.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Ugi peptide
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
uracil-mismatched DNA + H2O Homo sapiens
-
uracil + DNA with abasic site
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HT-29 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
uracil-mismatched DNA + H2O
-
Homo sapiens uracil + DNA with abasic site
-
?

Synonyms

Synonyms Comment Organism
UNG2 isoform Homo sapiens
uracil DNA glycosylase
-
Homo sapiens

General Information

General Information Comment Organism
malfunction inhibition of endogenous isoform UNG2 does not affect reverse transcription, permits integration of uracilated viruses but does not rescue viral protein expression Homo sapiens
physiological function isoform UNG2 initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration Homo sapiens