Protein Variants | Comment | Organism |
---|---|---|
D145N | the mutant shows increased class switch recombination efficiency and reduced uracil removal activity compared to the wild type enzyme | Mus musculus |
DELTA90/W231A | the mutant shows reduced class switch recombination efficiency and reduced deoxyuracil removal activity compared to the wild type enzyme | Mus musculus |
H268L | the mutant shows increased class switch recombination efficiency and reduced deoxyuracil removal activity compared to the wild type enzyme | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
uracil-mismatched single-stranded DNA + H2O | Mus musculus | - |
uracil + single-stranded DNA with abasic site | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
uracil-mismatched single-stranded DNA + H2O | - |
Mus musculus | uracil + single-stranded DNA with abasic site | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UNG | - |
Mus musculus |
uracil DNA glycosylase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | the DNA base excision repair enzyme is essential for class switch recombination | Mus musculus |