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Literature summary for 3.2.2.27 extracted from
- Interaction of the human cytomegalovirus uracil DNA glycosylase UL114 with the viral DNA polymerase catalytic subunit UL54 (2010), J. Gen. Virol., 91, 2029-2033.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of FLAG-tagged, His-tagged, or GST-tagged UL114 in recombinant virus, in Escherichia coli, and in the yeast two hybrid system | Human betaherpesvirus 5 |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Human betaherpesvirus 5 | UL114 and DNA polymerase catalytic subunit UL54 act in concert during base excision repair of the viral genome | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Human betaherpesvirus 5 | - |
HCMV | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| viral DNA polymerase accessory subunit UL44 and the DNA polymerase catalytic subunit UL54 copurifiy with UL114 by immunoprecipitation | Human betaherpesvirus 5 |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | UL114 and DNA polymerase catalytic subunit UL54 act in concert during base excision repair of the viral genome | Human betaherpesvirus 5 | ? | - |
? | |
| additional information | direct UL114-UL54 interaction. The UL54 carboxyl terminus is not required for UL54-UL114 interaction, but for UL114-UL44 interaction, overview | Human betaherpesvirus 5 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UL114 | - |
Human betaherpesvirus 5 |
| uracil DNA glycosylase | - |
Human betaherpesvirus 5 |
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