Protein Variants | Comment | Organism |
---|---|---|
additional information | siRNA knockdown of endogenous UNG2 in primary cells show that UNG2 is required for R5 but not X4HIV infection and that this requirement is bypassed when HIV enters the target cell via vesicular stomatitis virus envelope-glycoprotein-mediated endocytosis. siRNA knockdown of UNG2 in virus-producing primary cells leads to defective R5 HIV virions that are unable to complete viral cDNA synthesis, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | UNG2 of the human host is required by HIV-1 strain R5, but not by X4HIV, during the early stage of infection | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | UNG2 is highly expressed in the human embryonic kidney cell line 293T | Homo sapiens | - |
T-lymphocyte | low expression level of UNG2 | Homo sapiens | - |
TZM-bl cell | a HeLa-derived cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | UNG2 of the human host is required by HIV-1 strain R5, but not by X4HIV, during the early stage of infection | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UNG2 | - |
Homo sapiens |
uracil DNA glycosylase | - |
Homo sapiens |