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Literature summary for 3.2.2.27 extracted from

  • Jones, K.L.; Roche, M.; Gantier, M.P.; Begum, N.A.; Honjo, T.; Caradonna, S.; Williams, B.R.; Mak, J.
    X4 and R5 HIV-1 have distinct post-entry requirements for uracil DNA glycosylase during infection of primary cells (2010), J. Biol. Chem., 285, 18603-18614.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information siRNA knockdown of endogenous UNG2 in primary cells show that UNG2 is required for R5 but not X4HIV infection and that this requirement is bypassed when HIV enters the target cell via vesicular stomatitis virus envelope-glycoprotein-mediated endocytosis. siRNA knockdown of UNG2 in virus-producing primary cells leads to defective R5 HIV virions that are unable to complete viral cDNA synthesis, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens UNG2 of the human host is required by HIV-1 strain R5, but not by X4HIV, during the early stage of infection ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell UNG2 is highly expressed in the human embryonic kidney cell line 293T Homo sapiens
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T-lymphocyte low expression level of UNG2 Homo sapiens
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TZM-bl cell a HeLa-derived cell line Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information UNG2 of the human host is required by HIV-1 strain R5, but not by X4HIV, during the early stage of infection Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
UNG2
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Homo sapiens
uracil DNA glycosylase
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Homo sapiens