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Literature summary for 3.2.2.27 extracted from

  • Wanner, R.M.; Castor, D.; Guethlein, C.; Boettger, E.C.; Springer, B.; Jiricny, J.
    The uracil DNA glycosylase UdgB of Mycobacterium smegmatis protects the organism from the mutagenic effects of cytosine and adenine deamination (2009), J. Bacteriol., 191, 6312-6319.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.27

Cloned(Commentary)

Cloned (Comment) Organism
genes udgB and ung, phylogenetic analysis Mycolicibacterium smegmatis

Protein Variants

Protein Variants Comment Organism
additional information generation of udgB and ung knockout mutants by allelic replacement techniques. The general mutation frequency is increased in UDG knockout strains, frequencies of A:T to G:C mutations, which may arise through adenine deamination, in the udgB knockout mutant and in the double-knockout mutant are 10fold and 31fold higher that those in the wild-type strain, respectively, overview Mycolicibacterium smegmatis

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information association of Ung with the replication fork Mycolicibacterium smegmatis
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mycolicibacterium smegmatis UdgB removes aberrant bases uracil, from deaminated cytosine, and hypoxanthine, from deaminated adenine, and 5-fluorouracil from DNA with high efficiency ?
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 ?

Organism

Organism UniProt Comment Textmining
Mycolicibacterium smegmatis
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 genes udgB and ung
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information UdgB removes aberrant bases uracil, from deaminated cytosine, and hypoxanthine, from deaminated adenine, and 5-fluorouracil from DNA with high efficiency Mycolicibacterium smegmatis ?
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 ?

Synonyms

Synonyms Comment Organism
UdgB
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 Mycolicibacterium smegmatis
Ung-type uracil glycosylase
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 Mycolicibacterium smegmatis
uracil DNA glycosylase
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 Mycolicibacterium smegmatis

General Information

General Information Comment Organism
malfunction thymidylate synthase inhibition leads to UDG-dependent cell death Mycolicibacterium smegmatis
physiological function UdgB from Mycobacterium smegmatis protects this organism against mutagenesis associated with deamination of both cytosine and adenine. Together with Ung-type uracil glycosylase, UdgB also helps attenuate the cytotoxicity of the antimicrobial agent 5-fluorouracil Mycolicibacterium smegmatis