Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.2.27 extracted from

  • Parikh, S.S.; Putnam, C.D.; Tainer, J.A.
    Lessons learned from structural results on uracil-DNA glycosylase (2000), Mutat. Res., 460, 183-199.
    View publication on PubMed
Search for more literature for 3.2.2.27

Activating Compound

Activating Compound Comment Organism Structure
additional information UDG activity enhancement by AP endonuclease, mechanism, overview Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
UDG alone and bound to uncleaved substrate and product, X-ray diffraction structure determination and analysis, molecular modelling Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Ugi UDG inhibitor protein from Bacillus subtilis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens UDG initiates DNA base excision repair, BER, by hydrolyzing the uracil base from the deoxyribose. BER repairs a wide range of base lesions through the use of many different DNA glycosylases specific for distinct types of DNA damage, UDG activity is cell-cycle dependent and generally higher in proliferating cells than in non-cycling cells, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
Hydrolyses single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil the UDG active center contorts the uracil and deoxyribose while the phosphates 5' and 3' of the uridine are anchored by interactions with a proline-rich loop and a glycine-serine loop, UDG catalytic mechanism with channeling of DNA repair intermediates, overview Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information UDG initiates DNA base excision repair, BER, by hydrolyzing the uracil base from the deoxyribose. BER repairs a wide range of base lesions through the use of many different DNA glycosylases specific for distinct types of DNA damage, UDG activity is cell-cycle dependent and generally higher in proliferating cells than in non-cycling cells, overview Homo sapiens ?
-
 ?
uracil-mismatched double-stranded DNA + H2O uracil detection and nucleotide flipping by UDG, pinch–push–pull uracil detection mechanism, DNA binding structure, modelling, overview. The UDG shows preference for U-G mispairs compaired to U-A mispairs Homo sapiens uracil + double-stranded DNA with abasic site
-
 ?

Synonyms

Synonyms Comment Organism
UDG
-
 Homo sapiens