Literature summary for 3.2.2.27 extracted from

Chen, C.-Y.; Mosbaugh, D.W.; Bennett, S.E.
Mutations at arginine 276 transform human uracil-DNAglycosylase into a single-stranded DNA-specific uracil-DNA glycosylase (2005), DNA Repair, 4, 793-805.

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Protein Variants

Protein Variants	Comment	Organism
R276X	mutations at Arg276 transform uracil-DNA glycosylase into a single-stranded DNA-specific uracil-DNA glycosylase. The kcat of the R276 mutants is comparable to wild-type UNG on single-stranded DNA and differentially affected by NaCl, however, kcat on double-stranded DNA substrate is reduced 4-12-fold and decreases sharply at NaCl concentrations as low as 20 mM, the mutant proteins exhibit a 2.6 to 7.7fold reduction in affinity for a doubled-stranded oligonucleotide containing a pseudouracil residue opposite 2-aminopurine compared to the wild-type UNG	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P13051	-	-

Subunits

Subunits	Comment	Organism
More	structure of wild-type enzyme in complex with DNA, modelling, overview	Homo sapiens

Synonyms

Synonyms	Comment	Organism
UNG	-	Homo sapiens

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Release 2023.1 (January 2023)