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Literature summary for 3.2.2.23 extracted from

  • Smith, C.C.; ODonovan, M.R.; Martin, E.A.
    hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII (2006), Mutagenesis, 21, 185-190.
    View publication on PubMed

Application

Application Comment Organism
analysis comparison of human Ogg1, Escherichia coli Fpg and endonuclease III for the ability to modify the sensitivity of the comet assay. All three endonucleases recognize oxidative DNA damage and, in addition, Fpg and endonuclease III also recognize alkylation damage. Use of human Ogg1 in the modified comet assay offers a useful alternative to Fpg and is more specific for 8-oxoguanine and methyl-fapy-guanine Escherichia coli
analysis comparison of human Ogg1, Escherichia coli Fpg and endonuclease III for the ability to modify the sensitivity of the comet assay. Use of human Ogg1 in the modified comet assay offers a useful alternative to Fpg and is more specific for 8-oxoguanine and methyl-fapy-guanine Homo sapiens

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
isoform Fpg
-
Homo sapiens
-
isoform Ogg1
-