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Literature summary for 3.2.2.23 extracted from

  • Hamm, M.L.; Gill, T.J.; Nicolson, S.C.; Summers, M.R.
    Substrate specificity of Fpg (MutM) and hOGG1, two repair glycosylases (2007), J. Am. Chem. Soc., 129, 7724-7725.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000012
-
DNA containing 8-oxo-2'-deoxyguanosine
-
Escherichia coli
0.000012
-
DNA containing 8-oxo-2'-deoxyguanosine
-
Homo sapiens
0.000053
-
DNA containing 7-methyl-8-oxo-2'-deoxyguanosine
-
Escherichia coli
0.000083
-
DNA containing 7-deaza-2'-deoxyguanosine
-
Escherichia coli
0.000126
-
DNA containing 7-deaza-2'-deoxyguanosine
-
Homo sapiens
0.000137
-
DNA containing 7-methyl-8-oxo-2'-deoxyguanosine
-
Homo sapiens
0.000151
-
DNA containing 8-thio-2'-deoxyguanosine
-
Homo sapiens
0.000225
-
DNA containing 8-thio-2'-deoxyguanosine
-
Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
isoform Fpg
-
Homo sapiens
-
isoform hOGG1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing 7-deaza-2'-deoxyguanosine + H2O
-
Escherichia coli 7-deaza-2'-deoxyguanosine + DNA
-
?
DNA containing 7-deaza-2'-deoxyguanosine + H2O
-
Homo sapiens 7-deaza-2'-deoxyguanosine + DNA
-
?
DNA containing 7-methyl-8-oxo-2'-deoxyguanosine + H2O
-
Escherichia coli 7-methyl-8-oxo-2'-deoxyguanosine + DNA
-
?
DNA containing 7-methyl-8-oxo-2'-deoxyguanosine + H2O
-
Homo sapiens 7-methyl-8-oxo-2'-deoxyguanosine + DNA
-
?
DNA containing 8-oxo-2'-deoxyguanosine + H2O
-
Escherichia coli 8-oxo-2'-deoxyguanosine + DNA
-
?
DNA containing 8-oxo-2'-deoxyguanosine + H2O
-
Homo sapiens 8-oxo-2'-deoxyguanosine + DNA
-
?
DNA containing 8-thio-2'-deoxyguanosine + H2O
-
Escherichia coli 8-thio-2'-deoxyguanosine + DNA
-
?
DNA containing 8-thio-2'-deoxyguanosine + H2O
-
Homo sapiens 8-thio-2'-deoxyguanosine + DNA
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.00025
-
DNA containing 7-methyl-8-oxo-2'-deoxyguanosine
-
Homo sapiens
0.00045
-
DNA containing 8-thio-2'-deoxyguanosine
-
Escherichia coli
0.00045
-
DNA containing 8-thio-2'-deoxyguanosine
-
Homo sapiens
0.00051
-
DNA containing 7-methyl-8-oxo-2'-deoxyguanosine
-
Escherichia coli
0.00078
-
DNA containing 7-deaza-2'-deoxyguanosine
-
Homo sapiens
0.043
-
DNA containing 8-oxo-2'-deoxyguanosine
-
Homo sapiens
0.053
-
DNA containing 7-deaza-2'-deoxyguanosine
-
Escherichia coli
0.066
-
DNA containing 8-oxo-2'-deoxyguanosine
-
Escherichia coli