Application | Comment | Organism |
---|---|---|
medicine | C-terminal enzymatically active ricin A chain variants are specifically cleaved by HIV-1 protease both in vitro and in HIV-infected cells and the products mediate specific inhibitory effect towards HIV replication. Upon proteolysis, the processed variants show enhanced antiviral effect with low cytotoxicity towards uninfected cells | Ricinus communis |
Cloned (Comment) | Organism |
---|---|
the enzymatically active ricin A chain is expressed in Escherichia coli BL21(DE3)pLysS cells | Ricinus communis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
rRNA + H2O | Ricinus communis | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ricinus communis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
HisTrap column chromatography and Superdex 200 gel filtration | Ricinus communis |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
seed | - |
Ricinus communis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
rRNA + H2O | - |
Ricinus communis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ribosome-inactivating protein | - |
Ricinus communis |
ricin | - |
Ricinus communis |
RIP | - |
Ricinus communis |
RTA | enzymatically active ricin A chain | Ricinus communis |