Literature summary for 3.2.2.22 extracted from

Utskarpen, A.; Slagsvold, H.H.; Iversen, T.G.; Waelchli, S.; Sandvig, K.
Transport of ricin from endosomes to the Golgi apparatus is regulated by Rab6A and Rab6A (2006), Traffic, 7, 663-672.

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Application

Application	Comment	Organism
medicine	in HeLa cells, ricin transport to the trans-Golgi network is inhibited when the small GTPase Rab6A messenger RNA levels are reduced by more than 40% and less than 75%. However, when Rab6A mRNA is reduced by more than 75% and Rab6AmRNA is simultaneously up-regulated, the inhibition of ricin sulfation is abolished. The depletion of both Rab6A and Rab6A gives a stronger inhibition of ricin sulfation than what is observed knocking down the two isoforms separately	Ricinus communis

Organism

Organism	UniProt	Comment	Textmining
Ricinus communis	-	-	-

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Release 2023.1 (January 2023)