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Literature summary for 3.2.2.22 extracted from

  • Baykal, U.; Tumer, N.E.
    The C-terminus of pokeweed antiviral protein has distinct roles in transport to the cytosol, ribosome depurination and cytotoxicity (2007), Plant J., 49, 995-1007.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
C259A decrease in processing of the C-terminal extension Phytolacca americana
G75D no maturation of precursor form, localization exclusivelly in the membrane fraction Phytolacca americana
L252K delayed appearance of mature form in the cytosol Phytolacca americana
L252stop accumulation of the truncated protein primarily in the membrane fraction, at the lumenal side of microsomal membranes Phytolacca americana
N253A like wild-type, localization in the cytosol Phytolacca americana
N253R like wild-type, localization in the cytosol Phytolacca americana
N253stop reduced accumulation of the protein in the cytosol, appearance of a slightly larger form in the membrane fraction Phytolacca americana
T262stop present in both the membrane fraction and the cytosol Phytolacca americana
V73E no maturation of precursor form, reduced stability, localized to the lumenal side of microsomal membranes Phytolacca americana
Y254stop retains the ability to accumulate in the cytosol Phytolacca americana

Organism

Organism UniProt Comment Textmining
Phytolacca americana
-
pokeweed antiviral protein
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification enzyme is synthesized in pokeweed plants as a 313-amino-acid precursor with a 22-amino-acid N-terminal signal sequence and a 29-amino-acid C-terminal extension Phytolacca americana