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Literature summary for 3.2.2.22 extracted from

  • Gonzalez, T.V.; Farrant, S.A.; Mantis, N.J.
    Ricin induces IL-8 secretion from human monocyte/macrophages by activating the p38 MAP kinase pathway (2006), Mol. Immunol., 43, 1920-1923.
    View publication on PubMed

Application

Application Comment Organism
medicine ricin stimulates human monocyte/macrophage cell line 28SC to secrete interleukin IL-8. IL-8 induction can be blocked by brefeldin A. After ricin exposure, p38 mitogen activated protein kinase levels are elevated. Treatment of cells with p38 mitogen activated protein kinase inhibitor SB203580 suppresses ricin-mediated IL-8 release Ricinus communis

Organism

Organism UniProt Comment Textmining
Ricinus communis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ricin stimulates human monocyte/macrophage cell line 28SC to secrete interleukin IL-8. IL-8 induction can be blocked by brefeldin A. After ricin exposure, p38 mitogen activated protein kinase levels are elevated. Treatment of cells with p38 mitogen activated protein kinase inhibitor SB203580 suppresses ricin-mediated IL-8 release Ricinus communis ?
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