Literature summary for 3.2.2.22 extracted from

McCluskey, A.J.; Poon, G.M.; Bolewska-Pedyczak, E.; Srikumar, T.; Jeram, S.M.; Raught, B.; Gariepy, J.
The catalytic subunit of Shiga-like toxin 1 interacts with ribosomal stalk proteins and is inhibited by their conserved C-terminal domain (2008), J. Mol. Biol., 378, 375-386.

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Inhibitors

Inhibitors	Comment	Organism	Structure
KEESEESDDDMGFGLFD	peptide corresponding to the C-terminal 17 amino acids of human ribosomal proteins P1 and P2, inhibits the ribosome-inactivating function of A1 chain of shiga-like toxin 1	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	shiga-like toxin I	-

Subunits

Subunits	Comment	Organism
More	the A1 chain of shiga-like toxin 1 binds to the human ribosomal proteins P0, P1, and P2. Removal of the C-terminal 17 amino acids of either protein P1 or P2 abolishes the interaction, whereas P0 still binds to the A1 domain even without its C-terminus	Escherichia coli

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Release 2023.1 (January 2023)