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Literature summary for 3.2.2.22 extracted from
- CD38 as a target of IB4 mAb carrying saporin-S6: design of an immunotoxin for ex vivo depletion of hematological CD38+ neoplasia (2006), J. Biol. Regul. Homeost. Agents, 19, 145-152.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | coupling of an anti-CD38 monoclonal antibody to saporin-S6 and treatment of selected human CD38+ cell ines and CD38+ neoplastic cells from a NonHodgkin Lymphoma patient. In HBL6, Raji and L540 cells protein synthesis is completely inhibited by the conjugate at 100 pM. CD38+ cells from the patient wee completely eliminated after treatment at 10 nM while CFU-c rescue by bone marrow precursors was maintained | Saponaria officinalis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saponaria officinalis | - |
isoform saporin-S6 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| seed | - |
Saponaria officinalis | - |
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