Literature summary for 3.2.2.22 extracted from

Dawson, R.M.; Alderton, M.R.; Wells, D.; Hartley, P.G.
Monovalent and polyvalent carbohydrate inhibitors of ricin binding to a model of the cell-surface receptor (2006), J. Appl. Toxicol., 26, 247-252.

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Inhibitors

Inhibitors	Comment	Organism	Structure
beta-methyl galactoside	50% inhibition of ricin binding to immobilized asialofetuin in ELIZA-type assay at 1.78 mM, 50% inhibition in ricin cytotoxicity at 6.7 mM	Ricinus communis
beta-methyl lactoside	50% inhibition of ricin binding to immobilized asialofetuin in ELIZA-type assay at 0.55 mM, 50% inhibition in ricin cytotoxicity at 4.0 mM	Ricinus communis
D-galactose	50% inhibition of ricin binding to immobilized asialofetuin in ELIZA-type assay at 1.39 mM, 50% inhibition in ricin cytotoxicity at 65 mM	Ricinus communis
lactose	50% inhibition of ricin binding to immobilized asialofetuin in ELIZA-type assay at 0.74 mM, 50% inhibition in ricin cytotoxicity at 9.6 mM	Ricinus communis
additional information	coupling of galactose to the surface of dendrimers does not result in synergistic interactions	Ricinus communis

Organism

Organism	UniProt	Comment	Textmining
Ricinus communis	-	-	-

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Release 2023.1 (January 2023)