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Literature summary for 3.2.2.22 extracted from
- Ribosome depurination is not sufficient for ricin-mediated cell death in Saccharomyces cerevisiae (2007), Infect. Immun., 75, 417-428.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of precursor form of ricin A chain in Saccharomyces cerevisiae | Ricinus communis |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | isolation of mutants in ricin A chain inable to kill yeast cells when expressed in Saccharomyces cerevisiae. Several of the mutants depurinate ribosomes and inhibit translation to the same extent as wild-type, but cells expressing these mutants do not display hallmarks of apoptosis | Ricinus communis |
| P250L/A253V | mutant of ricin A chain, catalytically inactive, not cytotoxic in yeast | Ricinus communis |
| P95L/E145K | mutant of ricin A chain, catalytically active but not cytotoxic in yeast | Ricinus communis |
| S215F | mutant of ricin A chain, catalytically active but not cytotoxic in yeast | Ricinus communis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ricinus communis | - |
- |
- |
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Release 2023.1 (January 2023)
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