Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
rRNA + H2O | Saponaria officinalis | PAP causes translation arrest and is cytotoxic in targeted eukaryotic cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saponaria officinalis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
human mtDNA + H2O | saporin 6 shows specific nuclease activity towards the D-loop of human mitochondrial, covalently closed circular DNA, determination of sites of action by restriction analysis | Saponaria officinalis | ? | - |
? | |
rRNA + H2O | PAP causes translation arrest and is cytotoxic in targeted eukaryotic cells | Saponaria officinalis | ? | - |
? | |
rRNA + H2O | the ribotoxin depurinates a specific adenine in the highly conserved alpha-sarcin loop of the large subunit rRNA of eukaryotic ribosomes | Saponaria officinalis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
saporin 6 | - |
Saponaria officinalis |
single-chain ribosome-inactivating protein | - |
Saponaria officinalis |
type I ribosome-inactivating protein | - |
Saponaria officinalis |
type I RIP | - |
Saponaria officinalis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
21 | 37 | activity range, nuclease activity on mtDNA | Saponaria officinalis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | 7.8 | nuclease activity on mtDNA | Saponaria officinalis |