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Literature summary for 3.2.2.22 extracted from
- Pokeweed antiviral protein inhibits brome mosaic virus replication in plant cells (2005), J. Biol. Chem., 280, 20069-20075.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of wild-type PAP in yeast, and of mutant PAPs in Escherichia coli | Phytolacca americana |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of nontoxic mutant PAPs | Phytolacca americana |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Phytolacca americana |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| brome mosaic virus RNA + H2O | Phytolacca americana | depurination of the viral RNA, anti-viral activity of PAP by inhibition of accumulation of viral RNA and viral proliferation in barley protoplasts, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Phytolacca americana | - |
pokeweed | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| A4324 in 28S rRNA + H2O = deadenylated 28S rRNA + adenine | anti-viral mechanism of type 1 RIP pokeweed anti-viral protein PAP | Phytolacca americana |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| brome mosaic virus RNA + H2O | depurination of the viral RNA, anti-viral activity of PAP by inhibition of accumulation of viral RNA and viral proliferation in barley protoplasts, overview | Phytolacca americana | ? | - |
? | |
| brome mosaic virus RNA + H2O | depurination of the viral RNA | Phytolacca americana | ? | - |
? | |
| rRNA + H2O | depurination of rRNA in barley ribosomes | Phytolacca americana | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PAP | - |
Phytolacca americana |
| pokeweed antiviral protein | - |
Phytolacca americana |
| type I ribosome-inactivating protein | - |
Phytolacca americana |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Phytolacca americana |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Phytolacca americana |
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Release 2023.1 (January 2023)
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