Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a chimeric enzyme consisting of the A-chain of cinnamomin and the B-chain of ricin or vice versa, the enzyme possessing the cinnamomin B-chain shows lower cytotoxic effects, while the catalytic activity of the A-chains is similar, overview | Ricinus communis |
additional information | construction of a chimeric enzyme consisting of the A-chain of cinnamomin and the B-chain of ricin or vice versa, the enzyme possessing the cinnamomin B-chain shows lower cytotoxic effects, while the catalytic activity of the A-chains is similar, overview | Cinnamomum camphora |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Ricinus communis | the cytotoxic enzyme inhibits protein synthesis of the targeted BA/F3beta cells, the cytotoxicity is high compared to cinnamomin of Cinnamomum camphora due to the high affinity of the B-chain subunit for the cell surface ligands | ? | - |
? | |
additional information | Cinnamomum camphora | the cytotoxic enzyme inhibits protein synthesis of the targeted BA/F3beta cells, the cytotoxicity is low compared to ricin of Ricinus communis due to the low affinity of the B-chain subunit for the cell surface ligands | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cinnamomum camphora | - |
- |
- |
Ricinus communis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
seed | - |
Ricinus communis | - |
seed | - |
Cinnamomum camphora | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the cytotoxic enzyme inhibits protein synthesis of the targeted BA/F3beta cells, the cytotoxicity is high compared to cinnamomin of Cinnamomum camphora due to the high affinity of the B-chain subunit for the cell surface ligands | Ricinus communis | ? | - |
? | |
additional information | the cytotoxic enzyme inhibits protein synthesis of the targeted BA/F3beta cells, the cytotoxicity is low compared to ricin of Ricinus communis due to the low affinity of the B-chain subunit for the cell surface ligands | Cinnamomum camphora | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | heterodimer formed by a catalytic subunit A, the A-chain, and a carbohydrate binding subunit B, the B-chain | Ricinus communis |
dimer | heterodimer formed by a catalytic subunit A, the A-chain, and a carbohydrate binding subunit B, the B-chain | Cinnamomum camphora |
Synonyms | Comment | Organism |
---|---|---|
cinnamomin | - |
Cinnamomum camphora |
ricin | - |
Ricinus communis |
RNA N-glycosidase | - |
Ricinus communis |
RNA N-glycosidase | - |
Cinnamomum camphora |
type II ribosome-inactivating protein | - |
Ricinus communis |
type II ribosome-inactivating protein | - |
Cinnamomum camphora |
type II RIP | - |
Ricinus communis |
type II RIP | - |
Cinnamomum camphora |