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Literature summary for 3.2.2.21 extracted from

  • Leiros, I.; Nabong, M.P.; Gr?svik, K.; Ringvoll, J.; Haugland, G.T.; Uldal, L.; Reite, K.; Olsbu, I.K.; Knaevelsrud, I.; Moe, E.; Andersen, O.A.; Birkeland, N.K.; Ruoff, P.; Klungland, A.; Bjelland, S.
    Structural basis for enzymatic excision of N1-methyladenine and N3-methylcytosine from DNA (2007), EMBO J., 26, 2206-2217.
    View publication on PubMedView publication on EuropePMC
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Crystallization (Commentary)

Crystallization (Comment) Organism
at 1.8 A resolution. Structure contains two sodium ions in octahedral coordination Archaeoglobus fulgidus

Organism

Organism UniProt Comment Textmining
Archaeoglobus fulgidus
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alkylated DNA + H2O
-
 Archaeoglobus fulgidus 3-methyladenine + N3-methylcytosine + 1,N6-ethenoadenine + DNA excision of N3-methylcytosine is about twice as fast as excision of 3-methyladenine, and the rate for 1,N6-ethenoadenine is further 5-10 times higher ?