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Literature summary for 3.2.2.21 extracted from

  • Fishel, M.L.; Seo, Y.R.; Smith, M.L.; Kelley, M.R.
    Imbalancing the DNA base excision repair pathway in the mitochondria; targeting and overexpressing N-methylpurine DNA glycosylase in mitochondria leads to enhanced cell killing (2003), Cancer Res., 63, 608-615.
    View publication on PubMed
Search for more literature for 3.2.2.21

Application

Application Comment Organism
medicine overexpression of MPG can result in increased kill of tumor cells using lower doses of harmful alkylating agents such as temozolomide and cross-linking agents such as cisplatin, use of lower doses of chemotherapeutic agents, which will decrease the emergence of drug-resistant tumor cells and decrease the need fro stem-cell support, leading to an increased patient response and a better quality of life for the patient Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpressed in MDA-MB231 breast cancer cell line Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alkylated DNA + H2O Homo sapiens short-patch base excision repair pathway, repair of alkylation and oxidative DNA damage 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-
Homo sapiens
-
 MDA-MB231
-

Source Tissue

Source Tissue Comment Organism Textmining
MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alkylated DNA + H2O
-
 Homo sapiens 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?
alkylated DNA + H2O short-patch base excision repair pathway, repair of alkylation and oxidative DNA damage Homo sapiens 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?
additional information removes also hypoxanthine and 1,N6-ethenoadenine Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MPG
-
 Homo sapiens