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Literature summary for 3.2.2.21 extracted from

  • Cerda, S.R.; Turk, P.W.; Thor, A.D.; Weitzman, S.A.
    Altered expression of the DNA repair protein, N-methylpurine-DNA glycosylase (MPG) in breast cancer (1998), FEBS Lett., 431, 12-18.
    View publication on PubMed

Application

Application Comment Organism
medicine MPG overexpression is paradoxically associated with increased suspectibility to DNA damage, up-regulation of this gene may suggest a functional role in breast carcinogenesis, animal models using transgenic mice overexpressing the enzyme are being developed to determine the in vivo role of MPG in breast carcinogenesis Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
construction of recombinant GST-MPG fusion proteins Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alkylated DNA + H2O Homo sapiens
-
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell normal, malignant and immortalized breast cells Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
MCF10A cell immortalized, non-transformed breast epithelial cell line Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-
T47D cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alkylated DNA + H2O
-
Homo sapiens 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
additional information removes N-alkylpurine damage, unrepaired DNA damage leads to carcinogenesis, cell death, and aging, also releases 1,N6-ethenoadenine Homo sapiens ?
-
?