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Literature summary for 3.2.2.20 extracted from

  • Rajesh, S.; Sivaraman, T.
    Cheminformatic designing of de novo inhibitors to 3-methyl adenine DNA glycosylase I (LiTagA) from Leptospira interrogans serovar lai strain 56601 (2013), Med. Chem. Res., 22, 3434-3443.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
11-benzyl-11H-pyrido[3'2':5-6]pyrazino[2-3-b]indole
-
Leptospira interrogans
3-benzyladenine
-
Leptospira interrogans
3-butyladenine
-
Leptospira interrogans
3-ethyladenine
-
Leptospira interrogans
3-Methyladenine
-
Leptospira interrogans
3-propyladenine
-
Leptospira interrogans
benzyl-3H-imidazo[4,5-e][1,2,4]triazolo[1,5c][1,2,3]triazin-8(7H)-one
-
Leptospira interrogans
N-(4-tert-butyl-2-pyridinyl)-1-((4-tert-butyl-2-pyridinyl)imino)-1H-isoindol-3-amine
-
Leptospira interrogans
N-(5-methyl-2-pyridinyl)-1-((5-methyl-2-pyridinyl)imino)-1H-isoindol-3-amine
-
Leptospira interrogans
N-benzhydryl-9H-purin-6-amine
-
Leptospira interrogans
N2,N2-dimethyl-6,7-diphenyl-2,4-pteridinediamine
-
Leptospira interrogans
N4,N7,1-tribenzyl-1H-imidazo[4,5-d]pyridazine-4,7-diamine
-
Leptospira interrogans
N6-(5H-indeno[1,2-b]pyridin-3-ylmethyl)pteridine-2,4,6-triamine
-
Leptospira interrogans
N6-benzhydryl-9H-purine-2-6-diamine
-
Leptospira interrogans
N7-benzhydryl-3H-imidazo[4,5-b]pyridine-5,7-diamine
-
Leptospira interrogans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
22703
-
x * 22703, calculated from amino acid sequence Leptospira interrogans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alkylated DNA + H2O Leptospira interrogans
-
3-methyladenine + ?
-
?
alkylated DNA + H2O Leptospira interrogans
-
3-methylguanine + ?
-
?

Organism

Organism UniProt Comment Textmining
Leptospira interrogans Q8EZM1 serovar lai strain 56601
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alkylated DNA + H2O
-
Leptospira interrogans 3-methyladenine + ?
-
?
alkylated DNA + H2O
-
Leptospira interrogans 3-methylguanine + ?
-
?

Subunits

Subunits Comment Organism
? x * 22703, calculated from amino acid sequence Leptospira interrogans

Synonyms

Synonyms Comment Organism
3-methyl adenine DNA glycosylase I
-
Leptospira interrogans
TagA
-
Leptospira interrogans

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0004
-
pH and temperature not specified in the publication Leptospira interrogans 3-benzyladenine
0.0023
-
pH and temperature not specified in the publication Leptospira interrogans 3-butyladenine
0.005
-
pH and temperature not specified in the publication Leptospira interrogans 3-propyladenine
0.05
-
pH and temperature not specified in the publication Leptospira interrogans 3-ethyladenine
1.5
-
pH and temperature not specified in the publication Leptospira interrogans 3-Methyladenine