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Literature summary for 3.2.2.20 extracted from

  • Likhite, V.S.; Cass, E.I.; Anderson, S.D.; Yates, J.R.; Nardulli, A.M.
    Interaction of estrogen receptor alpha with 3-methyladenine DNA glycosylase modulates transcription and DNA repair (2004), J. Biol. Chem., 279, 16875-16882.
    View publication on PubMed
Search for more literature for 3.2.2.20

Cloned(Commentary)

Cloned (Comment) Organism
cloned and bacterially expressed as GST-MPG fusion protein Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alkylated DNA + H2O Homo sapiens nuclear transcription factor estrogen receptor alpha interacts with 3-methyladenine DNA glycosylase to modulate transcription and DNA repair, enzyme catalyzes removal of hypoxanthine from DNA, estrogen receptor alpha stabilizes the interaction of the enzyme with hypoxanthine containing DNAand increases the catalytic removal of the modified base 3-methyladenine + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human, U2-osteosarcoma, MCF-7
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
 Homo sapiens
-
U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alkylated DNA + H2O
-
 Homo sapiens 3-methyladenine + ?
-
 ?
alkylated DNA + H2O nuclear transcription factor estrogen receptor alpha interacts with 3-methyladenine DNA glycosylase to modulate transcription and DNA repair, enzyme catalyzes removal of hypoxanthine from DNA, estrogen receptor alpha stabilizes the interaction of the enzyme with hypoxanthine containing DNAand increases the catalytic removal of the modified base Homo sapiens 3-methyladenine + ?
-
 ?

Synonyms

Synonyms Comment Organism
MPG
-
 Homo sapiens