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Literature summary for 3.2.2.1 extracted from

  • Versees, W.; Decanniere, K.; Pelle, R.; Depoorter, J.; Brosens, E.; Parkin, D.W.; Steyaert, J.
    Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax (2001), J. Mol. Biol., 307, 1363-1379.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Trypanosoma vivax

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, unliganded structure and 3-deaza-adenosine complex Trypanosoma vivax

Inhibitors

Inhibitors Comment Organism Structure
3-deazaadenosine
-
Trypanosoma vivax
7-deazaadenosine
-
Trypanosoma vivax

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00382
-
guanosine pH 7.2, 35°C, His-tagged enzyme form Trypanosoma vivax
0.0052
-
Inosine pH 7.2, 35°C, without His-tag Trypanosoma vivax
0.00537
-
Inosine pH 7.2, 35°C, His-tagged enzyme form Trypanosoma vivax
0.00854
-
adenosine pH 7.2, 35°C, His-tagged enzyme form Trypanosoma vivax
0.586
-
uridine pH 7.2, 35°C, His-tagged enzyme form Trypanosoma vivax
0.925
-
cytidine pH 7.2, 35°C, His-tagged enzyme form Trypanosoma vivax
257
-
p-nitrophenylriboside pH 7.2, 35°C, His-tagged enzyme form Trypanosoma vivax

Organism

Organism UniProt Comment Textmining
Trypanosoma vivax Q9GPQ4
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Trypanosoma vivax

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine + H2O
-
Trypanosoma vivax adenine + D-ribose
-
?
cytidine + H2O
-
Trypanosoma vivax cytosine + D-ribose
-
?
guanosine + H2O
-
Trypanosoma vivax guanine + D-ribose
-
?
inosine + H2O
-
Trypanosoma vivax hypoxanthine + D-ribose
-
?
p-nitrophenylriboside + H2O
-
Trypanosoma vivax p-nitrophenol + D-ribose
-
?
uridine + H2O
-
Trypanosoma vivax uracil + D-ribose
-
?

Synonyms

Synonyms Comment Organism
IAG-NH
-
Trypanosoma vivax
inosine-adenosine-guanosine-preferring nucleoside hydrolase
-
Trypanosoma vivax

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.022
-
uridine pH 7.2, 35°C, His-tagged enzyme form Trypanosoma vivax
0.206
-
p-nitrophenylriboside pH 7.2, 35°C, His-tagged enzyme form Trypanosoma vivax
0.338
-
cytidine pH 7.2, 35°C, His-tagged enzyme form Trypanosoma vivax
1.46
-
adenosine pH 7.2, 35°C, His-tagged enzyme form Trypanosoma vivax
1.9
-
guanosine pH 7.2, 35°C, His-tagged enzyme form Trypanosoma vivax
5.19
-
Inosine pH 7.2, 35°C, His-tagged enzyme form Trypanosoma vivax
5.49
-
Inosine pH 7.2, 35°C, wiithout His-tag Trypanosoma vivax

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0002
-
3-deazaadenosine pH 7.2, 35°C, His-tagged enzyme form Trypanosoma vivax
0.3565
-
7-deazaadenosine pH 7.2, 35°C, His-tagged enzyme form Trypanosoma vivax