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Literature summary for 3.2.2.1 extracted from

  • Koszalka, G.W.; Krenitsky, T.A.
    Nucleosidases from Leishmania donovani. Pyrimidine ribonucleosidase, purine ribonucleosidase, and a novel purine 2-deoxyribonucleosidase (1979), J. Biol. Chem., 254, 8185-8193.
    View publication on PubMed
Search for more literature for 3.2.2.1

Inhibitors

Inhibitors Comment Organism Structure
2'-deoxyadenosine
-
 Leishmania mexicana
2'-deoxyinosine
-
 Leishmania mexicana
adenosine potent Leishmania mexicana
hypoxanthine arabinoside
-
 Leishmania mexicana
purine 2'-deoxyribonucleoside
-
 Leishmania mexicana
pyrazolo(3,4-d)pyrimidine
-
 Leishmania mexicana
Xanthosine moderate Leishmania mexicana

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
205000
-
 gel filtration Leishmania mexicana

Organism

Organism UniProt Comment Textmining
Leishmania mexicana
-
-
-

Storage Stability

Storage Stability Organism
-20°C, 5% loss of activity after 30 days Leishmania mexicana

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-mercaptopurine ribonucleoside + H2O
-
 Leishmania mexicana 6-mercaptopurine + ribose
-
 ?
adenosine + H2O no activity Leishmania mexicana D-ribose + adenine
-
 ?
guanosine + H2O
-
 Leishmania mexicana D-ribose + guanine
-
 ?
inosine + H2O
-
 Leishmania mexicana hypoxanthine + D-ribose
-
 ?
purine ribonucleoside + H2O
-
 Leishmania mexicana purine + D-ribose
-
 ?
xanthosine + H2O no activity Leishmania mexicana D-ribose + xanthine
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.7
-
-
 Leishmania mexicana