Activating Compound | Comment | Organism | Structure |
---|---|---|---|
N-benzyl-2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol | enhancement of beta-N-acetylhexosaminidase B activity at higher concentrations of inhibitor, whereas beta-N-acetylhexosaminidase A and/or beta-N-acetylhexosaminidase S activity are increased at much lower concentrations | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | 2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol, N-benzyl-2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol, and N-butyl-2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol are potent and selective inhibitors of beta-N-acetylhexosaminidase and may be useful as therapeutic agents for treating adult Tay-Sachs and Sandhoff diseases | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-acetamido-1,2,4-trideoxy-1,4-imino-D-arabinitol | poor inhibitor | Bos taurus | |
2-acetamido-1,2,4-trideoxy-1,4-imino-D-arabinitol | poor inhibitor | Canavalia sp. | |
2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol | - |
Bos taurus | |
2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol | noncompetitive inhibitor | Canavalia sp. | |
2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol | potent noncompetitive inhibitor | Homo sapiens | |
2-acetamido-1,2-dideoxy-1,5-imino-D-glucitol | competitive inhibitor | Homo sapiens | |
N-benzyl-2-acetamido-1,2,4-trideoxy-1,4-imino-D-arabinitol | potent inhibitor | Bos taurus | |
N-benzyl-2-acetamido-1,2,4-trideoxy-1,4-imino-D-arabinitol | competitive inhibitor | Canavalia sp. | |
N-benzyl-2-acetamido-1,2,4-trideoxy-1,4-imino-D-arabinitol | weak competitive inhibitor | Homo sapiens | |
N-benzyl-2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol | - |
Bos taurus | |
N-benzyl-2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol | noncompetitive inhibitor | Canavalia sp. | |
N-benzyl-2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol | potent noncompetitive inhibitor, inhibits human placenta beta-N-acetylhexosaminidase 2.5fold better than DNJ-NAc 13 | Homo sapiens | |
N-butyl-2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol | - |
Canavalia sp. |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Canavalia sp. | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Bos taurus | - |
additional information | GM3461 cell line | Homo sapiens | - |
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl-beta-N-acetylglucosamine + H2O | - |
Homo sapiens | 4-methylumbelliferol + N-acetyl-D-glucosamine | - |
? | |
4-methylumbelliferyl-beta-N-acetylglucosamine-6-sulfate + H2O | - |
Homo sapiens | 4-methylumbelliferol + N-acetyl-D-glucosamine-6-sulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta-N-acetylhexosaminidase A | - |
Homo sapiens |
beta-Nacetylhexosaminidase S | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000095 | - |
2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol | - |
Bos taurus | |
0.00028 | - |
N-benzyl-2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol | - |
Bos taurus | |
0.0037 | - |
N-benzyl-2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol | - |
Homo sapiens | |
0.0095 | - |
2-acetamido-1,2-dideoxy-1,5-imino-D-glucitol | - |
Homo sapiens | |
0.015 | - |
2-acetamido-1,2,4-trideoxy-1,4-imino-L-arabinitol | - |
Homo sapiens | |
0.0169 | - |
N-benzyl-2-acetamido-1,2,4-trideoxy-1,4-imino-D-arabinitol | - |
Bos taurus | |
0.104 | - |
2-acetamido-1,2,4-trideoxy-1,4-imino-D-arabinitol | - |
Bos taurus | |
0.18 | - |
N-benzyl-2-acetamido-1,2,4-trideoxy-1,4-imino-D-arabinitol | - |
Homo sapiens |