Crystallization (Comment) | Organism |
---|---|
in complex with iminocyclitol inhibitors. Compounds show time-dependent, slow-binding inhibition. Inhibitors that have an extra substituent at C1 residing at the beta position adopt a product-like 1C4 chair conformation rather than the transition-state 3H4 half-chair conformation | Thermotoga maritima |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R,3R,4R,5R,6S)-2-(aminomethyl)-6-methylpiperidine-3,4,5-triol | fuconojirimycin derivative, time dependent, slow-binding inhibition | Thermotoga maritima | |
(2S,3R,4S,5R)-2-(propan-2-yl)piperidine-3,4,5-triol | fuconojirimycin derivative, time dependent, slow-binding inhibition | Thermotoga maritima | |
(2S,3R,4S,5R)-2-benzylpiperidine-3,4,5-triol | fuconojirimycin derivative, time dependent, slow-binding inhibition | Thermotoga maritima | |
2-(1H-indol-3-yl)-N-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]acetamide | fuconojirimycin derivative, time dependent, slow-binding inhibition | Thermotoga maritima | |
2-cyclopentyl-2-phenyl-N-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]acetamide | fuconojirimycin derivative, time dependent, slow-binding inhibition | Thermotoga maritima | |
3-(1H-indol-3-yl)-N-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]propanamide | fuconojirimycin derivative, time dependent, slow-binding inhibition | Thermotoga maritima | |
N-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]-1-benzofuran-2-carboxamide | fuconojirimycin derivative, time dependent, slow-binding inhibition | Thermotoga maritima | |
N-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]-1H-indole-3-carboxamide | fuconojirimycin derivative, time dependent, slow-binding inhibition | Thermotoga maritima | |
N-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]acetamide | - |
Thermotoga maritima |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Thermotoga maritima | - |
- |
- |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000163 | - |
(2R,3R,4R,5R,6S)-2-(aminomethyl)-6-methylpiperidine-3,4,5-triol | - |
Thermotoga maritima | |
0.000105 | - |
3-(1H-indol-3-yl)-N-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]propanamide | - |
Thermotoga maritima | |
0.000427 | - |
N-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]-1H-indole-3-carboxamide | - |
Thermotoga maritima | |
0.000441 | - |
N-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]-1-benzofuran-2-carboxamide | - |
Thermotoga maritima | |
0.000475 | - |
2-(1H-indol-3-yl)-N-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]acetamide | - |
Thermotoga maritima | |
0.001 | - |
2-cyclopentyl-2-phenyl-N-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]acetamide | - |
Thermotoga maritima | |
0.0045 | - |
N-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]acetamide | - |
Thermotoga maritima | |
0.005 | - |
(2S,3R,4S,5R)-2-benzylpiperidine-3,4,5-triol | - |
Thermotoga maritima | |
0.006 | - |
(2S,3R,4S,5R)-2-(propan-2-yl)piperidine-3,4,5-triol | - |
Thermotoga maritima |