Literature summary for 3.2.1.51 extracted from

Laroche, C.; Behr, J.B.; Szymoniak, J.; Bertus, P.; Schuetz, C.; Vogel, P.; Plantier-Royon, R.
Spirocyclopropyl pyrrolidines as a new series of alpha-L-fucosidase inhibitors (2006), Bioorg. Med. Chem., 14, 4047-4054.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(5R,6R,7R)-6,7-dihydroxy-5-hydroxymethyl-4-azaspiro[2.4]heptane	1 mM, 50% inhibition	Bos taurus
(5R,6S,7S)-6,7-dihydroxy-5-hydroxymethyl-4-azaspiro[2.4]heptane	1 mM, 41% inhibition	Bos taurus
(5S,6R,7R)-6,7-dihydroxy-5-hydroxymethyl-4-azaspiro[2.4]heptane	1 mM, 49% inhibition	Bos taurus
(5S,6R,7S)-6,7-dihydroxy-5-hydroxymethyl-4-azaspiro[2.4]heptane	1 mM, 55% inhibition	Bos taurus
(5S,6R,7S)-6,7-dihydroxy-5-[(1S)-1,2-dihydroxyethyl]-4-azaspiro[2.4]heptane	1 mM,97 inhibition, competitive	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
p-nitrophenyl alpha-L-fucoside + H2O	-	Bos taurus	p-nitrophenol + alpha-L-fucose	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0016	-	(5S,6R,7S)-6,7-dihydroxy-5-[(1S)-1,2-dihydroxyethyl]-4-azaspiro[2.4]heptane	-	Bos taurus

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Release 2023.1 (January 2023)