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Literature summary for 3.2.1.51 extracted from

  • Dumas, D.P.; Kajimoto, T.; Liu, K.K.C.; Wong, C.H.
    Azasugars and glycal inhibitors of alpha-L-fucosidase (1992), Bioorg. Med. Chem. Lett., 2, 33-36.
No PubMed abstract available
Search for more literature for 3.2.1.51

Inhibitors

Inhibitors Comment Organism Structure
2-(hydroxymethyl)-5-methylpyrrolidine-3,4-diol competitive or uncompetitive inhibition, Ki: 0.004-26 mM, depending on conformation Bos taurus
2-methyltetrahydro-2H-pyran-3,4-diol uncompetitive inhibition, Ki: 23 mM Bos taurus
2-phenyl-tetrahydro-2H-pyran-3,4-diol uncompetitive inhibition, Ki: 22-83 mM, depending on conformation Bos taurus
4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate competitive inhibition, Ki: 0.09 mM Bos taurus
5-(hydroxymethyl)pyrrolidine-2,3,4-triol competitive inhibition, Ki: 0.91 mM Bos taurus
alpha-L-fucose competitive inhibition, Ki: 0.3 mM Bos taurus
D-1-deoxymannojirimycin competitive inhibition, Ki: 0.03 mM Bos taurus
D-1-deoxyrhamnojirimycin competitive inhibition, Ki: 0.011 mM Bos taurus
D-1-deoxytalonojirimycin competitive inhibition, Ki: 0.053 mM Bos taurus
D-fucal uncompetitive inhibition, Ki: 35 mM Bos taurus
L-1-deoxyfuconojirimycin competitive inhibition, Ki: 0.00003 mM Bos taurus
L-1-deoxymannojirimycin competitive inhibition, Ki: 90 mM Bos taurus
L-1-deoxyrhamnojirimycin competitive inhibition, Ki: 1 mM Bos taurus
L-fucal competitive inhibition, best inhibitor of glycal compounds tested, Ki: 0.05 mM Bos taurus
phenol noncompetitive inhibition, Ki: 112 mM Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 bovine
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl-alpha-L-fucopyranoside + H2O
-
 Bos taurus 4-nitrophenol + alpha-L-fucose
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00003
-
 L-1-deoxyfuconojirimycin competitive inhibition Bos taurus
0.004 26 2-(hydroxymethyl)-5-methylpyrrolidine-3,4-diol competitive or uncompetitive inhibition, depending on conformation Bos taurus
0.011
-
 D-1-deoxyrhamnojirimycin competitive inhibition Bos taurus
0.03
-
 D-1-deoxymannojirimycin competitive inhibition Bos taurus
0.05
-
 L-fucal competitive inhibition, best inhibitor of glycal compounds tested Bos taurus
0.053
-
 D-1-deoxytalonojirimycin competitive inhibition Bos taurus
0.09
-
 4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate competitive inhibition Bos taurus
0.91
-
 5-(hydroxymethyl)pyrrolidine-2,3,4-triol competitive inhibition Bos taurus
1
-
 L-1-deoxyrhamnojirimycin competitive inhibition Bos taurus
22 83 2-phenyl-tetrahydro-2H-pyran-3,4-diol uncompetitive inhibition, depending on conformation Bos taurus
23
-
 2-methyltetrahydro-2H-pyran-3,4-diol uncompetitive inhibition Bos taurus
35
-
 D-fucal uncompetitive inhibition Bos taurus
90
-
 L-1-deoxymannojirimycin competitive inhibition Bos taurus
112
-
 phenol noncompetitive inhibition Bos taurus