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Literature summary for 3.2.1.3 extracted from

  • Choubdar, N.; Sim, L.; Rose, D.R.; Pinto, B.M.
    Synthesis of 2-deoxy-2-fluoro and 1,2-ene derivatives of the naturally occurring glycosidase inhibitor, salacinol, and their inhibitory activities against recombinant human maltase glucoamylase (2008), Carbohydr. Res., 343, 951-956.
    View publication on PubMed
Search for more literature for 3.2.1.3

Inhibitors

Inhibitors Comment Organism Structure
2-deoxy-1-ene-salacinol synthesis, overview Homo sapiens
2-deoxy-2-fluorosalacinol synthesis, overview Homo sapiens
salacinol a naturally occurring glycosidase inhibitor isolated from roots and stems of a Sri Lankan plant, Salacia reticulata, the OH group on C-2 of salacinol is critical as a hydrogen-bond donor with functional groups in the active site of the enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens key intestinal enzymes involved in the breakdown of glucose ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl beta-D-glucoside + H2O
-
 Homo sapiens 4-nitrophenol + beta-D-glucose
-
 ?
additional information key intestinal enzymes involved in the breakdown of glucose Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
maltase glucoamylase
-
 Homo sapiens
MGA
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0002
-
 salacinol
-
 Homo sapiens
0.006
-
 2-deoxy-2-fluorosalacinol
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.15
-
-
 Homo sapiens 2-deoxy-1-ene-salacinol