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Literature summary for 3.2.1.3 extracted from
- Synthesis of analogues of salacinol containing a carboxylate inner salt and their inhibitory activities against human maltase glucoamylase (2007), Carbohydr. Res., 342, 1661-1667.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (2S,3S,4S)-1-[(2S,3S,4S)-4-carboxy-2,3,4-trihydroxybutyl]-3,4-dihydroxy-2-methoxytetrahydrothiophenium | a salacinol derivative, salacinol is a sulfonium ion with an internal sulfate counterion, synthesis of a compound with the D-arabinitol configuration in the heterocyclic ring displayed by salacinol, overview | Homo sapiens |  |
| 5-(1,4-dideoxy-1,4-episulfoniumylidene-D-arabinitol)-5-deoxy-D-ribonate inner salt | - |
Homo sapiens | |
| 5-(1,4-dideoxy-1,4-episulfoniumylidene-L-arabinitol)-5-deoxy-D-ribonate inner salt | - |
Homo sapiens | |
| blintol | - |
Homo sapiens | |
| ghavamiol | - |
Homo sapiens | |
| kotalanol | - |
Homo sapiens | |
| salacinol | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the key intestinal enzyme involved in the breakdown of glucose oligosaccharides in the small intestine | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| small intestine | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| maltose + H2O | - |
Homo sapiens | 2 D-glucose | - |
? | |
| additional information | the key intestinal enzyme involved in the breakdown of glucose oligosaccharides in the small intestine | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| maltase glucoamylase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
assay at | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
(2S,3S,4S)-1-[(2S,3S,4S)-4-carboxy-2,3,4-trihydroxybutyl]-3,4-dihydroxy-2-methoxytetrahydrothiophenium | pH 6.5, 37°C, derived from D-arabinitol, recombinant enzyme | Homo sapiens | |
| 0.021 | - |
salacinol | pH 6.5, 37°C, recombinant enzyme | Homo sapiens | |
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