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Literature summary for 3.2.1.24 extracted from

  • Racanicchi, L.; Montanucci, P.; Basta, G.P.; Pensato, A.; Conti, V.; Calafiore, R.
    Effect of all trans retinoic acid on lysosomal alpha-D-mannosidase activity in Hl-60 cell: correlation with Hl-60 cells differentiation (2008), Mol. Cell. Biochem., 308, 17-24.
    View publication on PubMed
Search for more literature for 3.2.1.24

Application

Application Comment Organism
diagnostics detection of enzymatic changes might relate to the pathogenesis of leukemia disease but also represent a potential peripheral diagnostic marker Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus alpha-D-mannosidase exists in multiple forms, which are detectable in most human tissues Homo sapiens 5794
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lysosome alpha-D-mannosidase exists in multiple forms, which are detectable in most human tissues Homo sapiens 5764
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
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Source Tissue

Source Tissue Comment Organism Textmining
granulocyte In normal granulocytes, specific enzymatic activities for both glycohydrolases (beta-D-hexosaminidase (EC 3.2.1.52) and alpha-D-mannosidase) are significantly lower in comparison with untreated HL-60 cells Homo sapiens
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HL-60 cell human promyelocytic leukemia HL-60 cells Homo sapiens
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 effects of all trans retinoic acid treatment of HL-60 on enzymatic activity of glycohydrolases tested Homo sapiens

Synonyms

Synonyms Comment Organism
alpha-D-mannosidase glycohydrolase Homo sapiens
alpha-mann
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 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
 alpha-D-mannosidase exists in multiple forms and can be classified on the basis of their optimum pH, into three groups Homo sapiens
4 4.5 lysosomal or acid mannosidases. Neutral optimum pH for endoplasmic reticulum-associated mannosidases Homo sapiens
5.5 6 Golgi compartment mannosidases. Neutral optimum pH for endoplasmic reticulum-associated mannosidases Homo sapiens