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Literature summary for 3.2.1.24 extracted from

  • Popowycz, F.; Gerber-Lemaire, S.; Demange, R.; Rodriguez-Garcia, E.; Asenjo, A.T.; Robina, I.; Vogel, P.
    Derivatives of (2R,3R,4S)-2-aminomethylpyrrolidine-3,4-diol are selective alpha-mannosidase inhibitors (2001), Bioorg. Med. Chem. Lett., 11, 2489-2493.
    View publication on PubMed
Search for more literature for 3.2.1.24

Inhibitors

Inhibitors Comment Organism Structure
(2R,3R,4S)-2-(aminomethyl)pyrrolidine-3,4-diol 1 mM, 81% inhibition, competitive Canavalia ensiformis
(2R,3R,4S)-2-(aminomethyl)pyrrolidine-3,4-diol 1 mM, 51% inhibition Prunus dulcis
(2R,3R,4S)-2-([[(1R)-1-hydroxyethyl]amino]methyl)pyrrolidine-3,4-diol 1 mM, 75% inhibition, competitive Canavalia ensiformis
(2R,3R,4S)-2-([[(1R)-1-hydroxyethyl]amino]methyl)pyrrolidine-3,4-diol 1 mM, 39% inhibition Prunus dulcis
(2R,3R,4S)-2-([[(1S)-1-hydroxyethyl]amino]methyl)pyrrolidine-3,4-diol 1 mM, 66% inhibition, competitive Canavalia ensiformis
(2R,3R,4S)-2-([[(1S)-1-hydroxyethyl]amino]methyl)pyrrolidine-3,4-diol 1 mM, 45% inhibition Prunus dulcis
(2R,3R,4S)-2-hydroxymethyl-pyrrolidine-3,4-diol 1 mM, 54% inhibition Canavalia ensiformis
(2R,3R,4S)-2-hydroxymethyl-pyrrolidine-3,4-diol 1 mM, 37% inhibition Prunus dulcis
(2R,3R,4S)-2-phenylaminomethyl-pyrrolidine-3,4-diol 1 mM, 92% inhibition, competitive Canavalia ensiformis
(2R,3R,4S)-2-phenylaminomethyl-pyrrolidine-3,4-diol 1 mM, 69% inhibition, competitive Prunus dulcis
(2R,3R,4S)-2-[(1-phenyl-ethylamino)-methyl]-pyrrolidine-3,4-diol 1 mM, 66% inhibition, competitive Canavalia ensiformis
(2R,3R,4S)-2-[(1-phenyl-ethylamino)-methyl]-pyrrolidine-3,4-diol 1 mM, 48% inhibition Prunus dulcis
(2R,3R,4S)-2-[(cyclopentylamino)methyl]pyrrolidine-3,4-diol 1 mM, 60% inhibition Canavalia ensiformis
(2R,3R,4S)-2-[(cyclopentylamino)methyl]pyrrolidine-3,4-diol 1 mM, 53% inhibition Prunus dulcis
(2R,3R,4S)-2-[2-(phenylamino)ethyl]pyrrolidine-3,4-diol 1 mM, 33% inhibition Canavalia ensiformis
(2R,3R,4S)-2-[[(1-benzyl-piperidin-4-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol 1 mM, 55% inhibition Canavalia ensiformis
(2R,3R,4S)-2-[[(1-benzyl-piperidin-4-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol 1 mM, 59% inhibition Prunus dulcis
(2R,3R,4S)-2-[[(2H-Imidazol-1-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol 1 mM, 55% inhibition Canavalia ensiformis
(2R,3R,4S)-2-[[(2H-Imidazol-1-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol 1 mM, 59% inhibition Prunus dulcis
(2R,3R,4S)-2-[[(furan-2-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol 1 mM, 49% inhibition Canavalia ensiformis
(2R,3R,4S)-2-[[(furan-2-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol 1 mM, 29% inhibition Prunus dulcis
(2R,3R,4S)-2-[[(thiophen-2-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol 1 mM, 89% inhibition, competitive Canavalia ensiformis
(2R,3R,4S)-2-[[(thiophen-2-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol 1 mM, 68% inhibition, competitive Prunus dulcis
(3S,4R)-pyrrolidine-3,4-diol 1 mM, 70% inhibition Canavalia ensiformis
(3S,4R)-pyrrolidine-3,4-diol 1 mM, 40% inhibition Prunus dulcis
2-(2,2-dihydroxy-ethyl)-pyrrolidine-3,4-diol 1 mM, 81% inhibition, mixed type Canavalia ensiformis
2-(2,2-dihydroxy-ethyl)-pyrrolidine-3,4-diol 1 mM, 56% inhibition Prunus dulcis
additional information no inhibition by (2R,3R,4S)-2-[(2-hydroxy-1-methyl-2,2-diphenyl-ethylamino)-methyl]-pyrrolidine-3,4-diol, and (2R,3R,4S)-2-(1,2-dihydroxy-ethyl)-pyrrolidine-3,4-diol Canavalia ensiformis
additional information no inhibition by (2R,3R,4S)-2-[(2-hydroxy-1-methyl-2,2-diphenyl-ethylamino)-methyl]-pyrrolidine-3,4-diol, (2R,3R,4S)-2-(1,2-dihydroxy-ethyl)-pyrrolidine-3,4-diol, and (2R,3R,4S)-2-[2-(phenylamino)ethyl]pyrrolidine-3,4-diol Prunus dulcis

Organism

Organism UniProt Comment Textmining
Canavalia ensiformis
-
-
-
Prunus dulcis
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0074
-
 (2R,3R,4S)-2-[[(2H-Imidazol-1-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol 35°C Canavalia ensiformis
0.026
-
 (2R,3R,4S)-2-[[(thiophen-2-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol 35°C Canavalia ensiformis
0.053
-
 (2R,3R,4S)-2-(aminomethyl)pyrrolidine-3,4-diol 35°C Canavalia ensiformis
0.059
-
 (2R,3R,4S)-2-([[(1R)-1-hydroxyethyl]amino]methyl)pyrrolidine-3,4-diol 35°C Canavalia ensiformis
0.06
-
 (2R,3R,4S)-2-phenylaminomethyl-pyrrolidine-3,4-diol 35°C Canavalia ensiformis
0.071
-
 (2R,3R,4S)-2-phenylaminomethyl-pyrrolidine-3,4-diol 35°C Prunus dulcis
0.08
-
 2-(2,2-dihydroxy-ethyl)-pyrrolidine-3,4-diol 35°C Canavalia ensiformis
0.098
-
 (2R,3R,4S)-2-[[(thiophen-2-ylmethyl)-amino]-methyl]-pyrrolidine-3,4-diol 35°C Prunus dulcis
0.12
-
 (2R,3R,4S)-2-([[(1S)-1-hydroxyethyl]amino]methyl)pyrrolidine-3,4-diol 35°C Canavalia ensiformis
0.17
-
 (2R,3R,4S)-2-[(1-phenyl-ethylamino)-methyl]-pyrrolidine-3,4-diol 35°C Canavalia ensiformis