Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Co2+ | inhibition of alpha-mannosidases IA and IB | Rattus sp. | |
Cu2+ | inhibition of alpha-mannosidases IA, IB and II | Rattus sp. | |
EDTA | inhibitory for alpha-mannosidases IA and IB | Rattus sp. | |
methyl-alpha-D-mannopyranoside | slight inhibitory for alpha-mannosidases IA and IB | Rattus sp. | |
p-chloromercuribenzenesulfonic acid | different inhibition rates for alpha-mannosidases IA, IB and II | Rattus sp. | |
Tris | inhibitory for alpha-mannosidases IA and IB | Rattus sp. | |
Zn2+ | slight inhibition for alpha-mannosidase IA | Rattus sp. |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | 3 isoforms, alpha-mannosidases IA, IB and II | Rattus sp. | 5794 | - |
membrane | from Golgi-enriched membrane fraction | Rattus sp. | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | slight activation for alpha-mannosidase II | Rattus sp. | |
Zn2+ | slight activation for alpha-mannosidase II | Rattus sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Man9-5GlcNAc + 4 H2O | Rattus sp. | different product composition for alpha-mannosidases IA, IB and II | Man5-3GlcNAc + 4 alpha-D-mannopyranose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus sp. | - |
- |
- |
Purification (Comment) | Organism |
---|---|
to homogeneity, chromatography steps | Rattus sp. |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus sp. | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Man9-5GlcNAc + 4 H2O | different product composition for alpha-mannosidases IA, IB and II | Rattus sp. | Man5-3GlcNAc + 4 alpha-D-mannopyranose | - |
? | |
p-nitrophenyl-alpha-D-mannopyranoside + H2O | isoforms mannosidase IB and II | Rattus sp. | p-nitrophenol + alpha-D-mannopyranose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Golgi alpha-mannosidase II | - |
Rattus sp. |
Golgi mannosidase IA | - |
Rattus sp. |
Golgi mannosidase IB | - |
Rattus sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
alpha-mannosidase II with p-nitrophenyl-alpha-D-mannopyranoside as substrate | Rattus sp. |
5.8 | - |
alpha-mannosidase II with Man8GlcNAc as substrate | Rattus sp. |
6 | - |
alpha-mannosidases IA and IB with Man8GlcNAc as substrate | Rattus sp. |