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Literature summary for 3.2.1.24 extracted from

  • Porwoll, S.; Fuchs, H.; Tauber, R.
    Characterization of a soluble class I alpha-mannosidase in human serum (1999), FEBS Lett., 449, 175-178.
    View publication on PubMed
Search for more literature for 3.2.1.24

Inhibitors

Inhibitors Comment Organism Structure
1-deoxymannojirimicin complete inhibition at 1 mM Homo sapiens
EDTA complete inhibition at 20 mM, activity recovered in the presence of Ca2+ Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Man9GlcNAc2 + H2O Homo sapiens involved in N-glycan processing to form oligomannosidic glycans during glycoprotein biosynthesis, cleaves three of the four alpha-1,2-mannosidic linkages Man5GlcNAc2 + Man6GlcNAc2 + Man7GlcNAc2 + Man8GlcNAc2 + alpha-D-mannopyranose major product: Man6GlcNAc2 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Man9GlcNAc2 + H2O involved in N-glycan processing to form oligomannosidic glycans during glycoprotein biosynthesis, cleaves three of the four alpha-1,2-mannosidic linkages Homo sapiens Man5GlcNAc2 + Man6GlcNAc2 + Man7GlcNAc2 + Man8GlcNAc2 + alpha-D-mannopyranose major product: Man6GlcNAc2 ?

Synonyms

Synonyms Comment Organism
alpha 1,2-mannosidase
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
-
 Homo sapiens

pH Stability

pH Stability pH Stability Maximum Comment Organism
7 7.5 30-64% remaining activity Homo sapiens