Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.21 extracted from

  • Daniels, L.B.; Coyle, P.J.; Chiao, Y.B.; Glew, R.H.
    Purification and characterization of a cytosolic broad specificity beta-glucosidase from human liver (1981), J. Biol. Chem., 256, 13004-13013.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Gaucher spleen heat-stable factor 15fold increase for hydrolysis of 17beta-estradiol-17'-beta-D-glucoside Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,6-hexane diamine 23.9% inhibition at 10 mM Homo sapiens
D-glucono-1,5-lactone 87.5% inhibition at 10 mM Homo sapiens
D-gluconylhydrazide 31.8% inhibition at 10 mM Homo sapiens
N-(6-aminohexyl)-D-gluconamide 13.4% inhibition at 10 mM Homo sapiens
sodium taurocholate 58% inhibition at 1.2% Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.034
-
4-methylumbelliferyl beta-D-fucoside
-
Homo sapiens
0.062
-
4-methylumbelliferyl-beta-D-glucoside
-
Homo sapiens
0.1
-
4-methylumbelliferyl alpha-L-arabinoside
-
Homo sapiens
0.14
-
4-methylumbelliferyl-beta-D-galactoside
-
Homo sapiens
0.34
-
4-methylumbelliferyl-beta-D-xyloside
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
53000
-
gel filtration, native PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity, chromatography techniques, isoelectric focusing Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver from type 1 Gaucher disease Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.08
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-estradiol 17-beta-D-glucoside + H2O
-
Homo sapiens beta-D-glucose + 17beta-estradiol
-
?
17beta-estradiol-3'-beta-D-glucoside + H2O poor activity Homo sapiens beta-D-glucose + 17beta-estradiol
-
?
2,4-dinitrophenyl-beta-D-galactoside + H2O
-
Homo sapiens 2,4-dinitrophenol + beta-D-galactose
-
?
2-nitrophenyl beta-D-glucopyranoside + H2O
-
Homo sapiens 2-nitrophenol + D-glucopyranose
-
?
2-nitrophenyl-alpha-L-arabinoside + H2O very low activity Homo sapiens 2-nitrophenol + alpha-L-arabinose
-
?
4-methylumbelliferyl alpha-L-arabinoside + H2O
-
Homo sapiens 4-methylumbelliferone + alpha-L-arabinose
-
?
4-methylumbelliferyl beta-D-fucoside + H2O
-
Homo sapiens 4-methylumbelliferone + beta-D-fucose
-
?
4-methylumbelliferyl-beta-D-galactopyranoside + H2O
-
Homo sapiens 4-methylumbelliferone + beta-D-galactopyranose
-
?
4-methylumbelliferyl-beta-D-glucoside + H2O
-
Homo sapiens 4-methylumbelliferone + beta-D-glucose
-
?
4-methylumbelliferyl-beta-D-xylopyranoside + H2O
-
Homo sapiens 4-methylumbelliferone + beta-D-xylopyranose
-
?
4-nitrophenyl beta-D-galactoside + H2O
-
Homo sapiens 4-nitrophenol + beta-D-galactose
-
?
estrone-3-beta-D-glucoside + H2O poor activity Homo sapiens beta-D-glucose + estrone
-
?
lactobionic acid + H2O very low activity Homo sapiens ?
-
?
phenylethyl-beta-D-galactoside + H2O very poor substrate Homo sapiens phenylethanol + beta-D-galactose
-
?

Subunits

Subunits Comment Organism
monomer 1 * 53000, SDS-PAGE Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
half-life: 22-24 min, 2fold enhanced stability of Gaucher disease liver enzyme compared to control liver Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 6
-
Homo sapiens