Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Gaucher spleen heat-stable factor | 15fold increase for hydrolysis of 17beta-estradiol-17'-beta-D-glucoside | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,6-hexane diamine | 23.9% inhibition at 10 mM | Homo sapiens | |
D-glucono-1,5-lactone | 87.5% inhibition at 10 mM | Homo sapiens | |
D-gluconylhydrazide | 31.8% inhibition at 10 mM | Homo sapiens | |
N-(6-aminohexyl)-D-gluconamide | 13.4% inhibition at 10 mM | Homo sapiens | |
sodium taurocholate | 58% inhibition at 1.2% | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.034 | - |
4-methylumbelliferyl beta-D-fucoside | - |
Homo sapiens | |
0.062 | - |
4-methylumbelliferyl-beta-D-glucoside | - |
Homo sapiens | |
0.1 | - |
4-methylumbelliferyl alpha-L-arabinoside | - |
Homo sapiens | |
0.14 | - |
4-methylumbelliferyl-beta-D-galactoside | - |
Homo sapiens | |
0.34 | - |
4-methylumbelliferyl-beta-D-xyloside | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
53000 | - |
gel filtration, native PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
to homogeneity, chromatography techniques, isoelectric focusing | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | from type 1 Gaucher disease | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
7.08 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17beta-estradiol 17-beta-D-glucoside + H2O | - |
Homo sapiens | beta-D-glucose + 17beta-estradiol | - |
? | |
17beta-estradiol-3'-beta-D-glucoside + H2O | poor activity | Homo sapiens | beta-D-glucose + 17beta-estradiol | - |
? | |
2,4-dinitrophenyl-beta-D-galactoside + H2O | - |
Homo sapiens | 2,4-dinitrophenol + beta-D-galactose | - |
? | |
2-nitrophenyl beta-D-glucopyranoside + H2O | - |
Homo sapiens | 2-nitrophenol + D-glucopyranose | - |
? | |
2-nitrophenyl-alpha-L-arabinoside + H2O | very low activity | Homo sapiens | 2-nitrophenol + alpha-L-arabinose | - |
? | |
4-methylumbelliferyl alpha-L-arabinoside + H2O | - |
Homo sapiens | 4-methylumbelliferone + alpha-L-arabinose | - |
? | |
4-methylumbelliferyl beta-D-fucoside + H2O | - |
Homo sapiens | 4-methylumbelliferone + beta-D-fucose | - |
? | |
4-methylumbelliferyl-beta-D-galactopyranoside + H2O | - |
Homo sapiens | 4-methylumbelliferone + beta-D-galactopyranose | - |
? | |
4-methylumbelliferyl-beta-D-glucoside + H2O | - |
Homo sapiens | 4-methylumbelliferone + beta-D-glucose | - |
? | |
4-methylumbelliferyl-beta-D-xylopyranoside + H2O | - |
Homo sapiens | 4-methylumbelliferone + beta-D-xylopyranose | - |
? | |
4-nitrophenyl beta-D-galactoside + H2O | - |
Homo sapiens | 4-nitrophenol + beta-D-galactose | - |
? | |
estrone-3-beta-D-glucoside + H2O | poor activity | Homo sapiens | beta-D-glucose + estrone | - |
? | |
lactobionic acid + H2O | very low activity | Homo sapiens | ? | - |
? | |
phenylethyl-beta-D-galactoside + H2O | very poor substrate | Homo sapiens | phenylethanol + beta-D-galactose | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 53000, SDS-PAGE | Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
half-life: 22-24 min, 2fold enhanced stability of Gaucher disease liver enzyme compared to control liver | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5 | 6 | - |
Homo sapiens |