Literature summary for 3.2.1.14 extracted from

Olland, A.M.; Strand, J.; Presman, E.; Czerwinski, R.; Joseph-McCarthy, D.; Krykbaev, R.; Schlingmann, G.; Chopra, R.; Lin, L.; Fleming, M.; Kriz, R.; Stahl, M.; Somers, W.; Fitz, L.; Mosyak, L.
Triad of polar residues implicated in pH specificity of acidic mammalian chitinase (2009), Protein Sci., 18, 569-578.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
AMCase catalytic domain in the apo form and in complex with the inhibitor methylallosamidin, X-ray diffraction structure determination and analysis at 1.7-2.0 A resolution	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
S354F	site-directed mutagenesis of the glycosylation site rsidue	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
methylallosamidin	complex formation with the enzyme and binding structure analysis, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	AMCase is a mammalian chitinase that is implicated in allergic asthma	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BZP6	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	N-glycosylation at Ser354	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	AMCase is a mammalian chitinase that is implicated in allergic asthma	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
acidic mammalian chitinase	-	Homo sapiens
AMCase	-	Homo sapiens

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Release 2023.1 (January 2023)