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Literature summary for 3.2.1.14 extracted from

  • Arora, M.; Chen, L.; Paglia, M.; Gallagher, I.; Allen, J.E.; Vyas, Y.M.; Ray, A.; Ray, P.
    Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells (2006), Proc. Natl. Acad. Sci. USA, 103, 7777-7782.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.14

Activating Compound

Activating Compound Comment Organism Structure
additional information simvastatin and Th-2 cytokins induces expression of Ym1 in dendritic cells and macrophages, respectively Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular Ym1 is expressed on the plasma membrane and secreted Mus musculus
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plasma membrane Ym1 is expressed on the plasma membrane and secreted Mus musculus 5886
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus simvastatin promotes Th2-type responses through the induction of Ym1 in dendritic cells, mechanism, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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 BALB/c mice, STAT-6-/- mice, and IL-4Ralpha-/- mice
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Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
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 Mus musculus
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dendritic cell from spleen Mus musculus
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additional information Ym1 belongs to the chitinase family Mus musculus
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spleen
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information simvastatin promotes Th2-type responses through the induction of Ym1 in dendritic cells, mechanism, overview Mus musculus ?
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 ?
additional information Ym1 is a lectin with heparin-binding characteristics and belongs to the chitinase family, but does not show chitinase activity Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
B220
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 Mus musculus
Ym1
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 Mus musculus