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Literature summary for 3.1.4.4 extracted from

  • Greco, E.; Santucci, M.B.; Quintiliani, G.; Papi, M.; De Spirito, M.; Fraziano, M.
    CpG oligodeoxynucleotides promote phospholipase D dependent phagolysosome maturation and intracellular mycobacterial killing in M. tuberculosis infected type II alveolar epithelial cells (2009), Cell. Immunol., 259, 1-4.
    View publication on PubMed
Search for more literature for 3.1.4.4

Activating Compound

Activating Compound Comment Organism Structure
CpG oligodeoxynucleotides induce PLD activation, increase PLD activity, PLD-dependent reactive oxygen intermediate production, PLD-dependent phagolysosome maturation, and PLD-dependent intracellular mycobacterial killing in type II alveolar epithelial cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ethanol
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell native or infected with Mycobacterium tuberculosis strain H73Rv, that is localized in endosomes at immature stage, CpG oligodeoxynucleotides treatment promotes maturation to mature phagolysosomes Homo sapiens
-
alveolar cell type II
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
PLD
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function PLD activity is a key enzyme involved in CpG oligodeoxynucleotides-induced intracellular mycobacterial killing in human monocytes/macrophages. Phagolysosome biogenesis from endosomes appears to be mediated by PLD activation, which is inhibited by ethanol in vivo in A-549 cells, overview Homo sapiens