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Literature summary for 3.1.4.39 extracted from

  • Rancoule, C.; Dusaulcy, R.; Treguer, K.; Gres, S.; Attane, C.; Saulnier-Blache, J.S.
    Involvement of autotaxin/lysophosphatidic acid signaling in obesity and impaired glucose homeostasis (2014), Biochimie, 96, 140-143.
    View publication on PubMed
Search for more literature for 3.1.4.39

Protein Variants

Protein Variants Comment Organism
additional information generation of adipocyte-specific knockout FATX-KO mice Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Mus musculus
-
-
extracellular the enzyme is secreted Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
 Mus musculus
-
adipocyte
-
 Homo sapiens
-
additional information the enzyme is abundantly secreted by adipose tissue where it is 2-3 times more expressed in adipocytes than in the stromal-vascular cells containing, among others, the preadipocytes Mus musculus
-

Synonyms

Synonyms Comment Organism
ATX
-
 Mus musculus
ATX
-
 Homo sapiens
autotaxin
-
 Mus musculus
autotaxin
-
 Homo sapiens
lysophospholipase D
-
 Mus musculus
lysophospholipase D
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus enzyme expression is up-regulated in obese mice in relationship with insulin resistance and impaired glucose tolerance up
Homo sapiens enzyme expression is up-regulated in obese patients in relationship with insulin resistance and impaired glucose tolerance up

General Information

General Information Comment Organism
malfunction adipocyte-specific knockout FATX-KO mice or mice treated with the lysophosphatidic acid receptor antagonist Ki16425 gain more weight and accumulate more adipose tissue than wild-type or control mice fed a high fat diet Mus musculus
physiological function the enzyme is involved in synthesis of lysophosphatidic acid, a phospholipid growth factor acting via lysophosphatidic acid-specific receptors (LPA1R to LPA6R) and involved in several pathologies including obesity. Enzyme expression is up-regulated in obese patients and mice in relationship with insulin resistance and impaired glucose tolerance. Lysophosphatidic acid-specific receptor LPA1R is the most abundant receptor subtype in adipose tissue. Its expression is higher in non-adipocyte cells than in adipocytes and is not altered in obesity. The enzyme increases and receptor LPA1R decreases while preadipocytes differentiate into adipocytes (adipogenesis). Lysophosphatidic acid inhibits adipogenesis through down-regulation of the pro-adipogenic transcription factor PPARgamma2. ATX/LPA signaling impairs glucose homeostasis, regulation of obesity involves the enzyme, overview Mus musculus
physiological function the enzyme is involved in synthesis of lysophosphatidic acid, a phospholipid growth factor acting via specific receptors (LPA1R to LPA6R) and involved in several pathologies including obesity. ATX/LPA signaling impairs glucose homeostasis, regulation of obesity involves the enzyme, overview Homo sapiens