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Literature summary for 3.1.4.39 extracted from

  • David, M.; Wannecq, E.; Descotes, F.; Jansen, S.; Deux, B.; Ribeiro, J.; Serre, C.M.; Gres, S.; Bendriss-Vermare, N.; Bollen, M.; Saez, S.; Aoki, J.; Saulnier-Blache, J.S.; Clezardin, P.; Peyruchaud, O.
    Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts (2010), PLoS ONE, 5, e9741.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.39

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
4T1 cell
-
 Mus musculus
-
MDA-MB-231-B02 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lysophosphatidylcholine + H2O
-
 Mus musculus lysophosphatidic acid + choline
-
 ?
lysophosphatidylcholine + H2O
-
 Homo sapiens lysophosphatidic acid + choline
-
 ?

Synonyms

Synonyms Comment Organism
ATX
-
 Mus musculus
ATX
-
 Homo sapiens
autotaxin
-
 Mus musculus
autotaxin
-
 Homo sapiens
lysophospholipase D
-
 Mus musculus
lysophospholipase D
-
 Homo sapiens
lysoPLD
-
 Mus musculus
lysoPLD
-
 Homo sapiens
NPP2
-
 Mus musculus
NPP2
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction down-regulation of endogenous autotaxin expression in 4T1 cells inhibits osteolytic bone metastasis formation independently of primary tumor growth in vivo Mus musculus
physiological function expression of autotaxin by cancer cells controls osteolytic bone metastasis formation Mus musculus
physiological function expression of autotaxin by cancer cells controls osteolytic bone metastasis formation Homo sapiens